Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)

ADC ID	DRG0ZBACG
ADC Name	CN106188293A ADC-12
Synonyms	CN106188293A_ADC 12 Click to Show/Hide
Organization	Jiangsu Hengrui Pharmaceuticals Co.,Ltd
Drug Status	Investigative
Indication	In total 4 Indication(s) Hepatocellular carcinoma [ICD11:2C12] Investigative Lung cancer [ICD11:2C25] Investigative Pancreatic cancer [ICD11:2C10] Investigative Renal cell carcinoma [ICD11:2C90] Investigative
Drug-to-Antibody Ratio	1.6
	3D MOL	2D MOL
Antibody Name	Anti-MET mAb Ab-10		Antibody Info
Antigen Name	Hepatocyte growth factor receptor (MET)		Antigen Info
Payload Name	Undisclosed
Linker Name	CN106188293A_ADC-12LacNAc-based glycosite-specific conjudate through reduced inter-chain cysteines

General Information of The Activity Data Related to This ADC

Revealed Based on the Cell Line Data

Click To Hide/Show 1 Activity Data Related to This Level

Standard Type	Value	Units	Cell Line	Disease Model
Half Maximal Inhibitory Concentration (IC50)	0.59	nM	CVCL_0434	Gastric adenocarcinoma

Full List of Activity Data of This Antibody-drug Conjugate

Revealed Based on the Cell Line Data

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	0.59 nM	Positive MET expression (MET+++/++)
Method Description	The MTS cell proliferation assay was performed as follows: CellTiter 96 Aqueous Non-Radioactive Cell proliferation Kit is used to determine the number of viable cells in cell proliferation assay. Tumor cells are plated at certain seeding densities in sterile 384-well black clear bottom Matrix plates at 40 uL per well and incubated overnight at 37°C in 5% CO₂ before assaying. Click to Show/Hide
In Vitro Model	Gastric adenocarcinoma	MKN45 cells		CVCL_0434

References

Ref 1	Anti-C-met antibodies and anti-C-met antibodies-cytotoxic drug conjugate and medical usage thereof.