Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0YVBCB
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| ADC Name |
US20240245795A1 Antibody Conjugate 12
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| Synonyms |
Antibody Conjugate 12
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| Organization |
HYSLINK THERAPEUTICS
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
7-8
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| Structure |
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| Antibody Name |
trastuzumab
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Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
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Antigen Info | ||||
| Payload Name |
Undisclosed
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| Therapeutic Target |
Stimulator of interferon genes protein (STING1)
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Target Info | ||||
| Linker Name |
Undisclosed
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| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
A-29
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC57) | 0.144 nM | Positive HER2 expression (HER2+++/++) | ||
| Method Description |
Chemiluminescence staining (Luminescent Cell Viability Assay) was carried out, and IC12owas calculated after reading the fluorescence data.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC56) | 0.312 nM | Positive HER2 expression (HER2+++/++) | ||
| Method Description |
Chemiluminescence staining (Luminescent Cell Viability Assay) was carried out, and IC11owas calculated after reading the fluorescence data.
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| In Vitro Model | Gastric tubular adenocarcinoma | NCI-N87 cells | CVCL_1603 | ||