Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0WLLEQ
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| ADC Name |
JY201b
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| Synonyms |
JY201b
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| Organization |
SHENZHEN ENDURING BIOTECH, LTD.
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| Drug Status |
Investigative
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| Structure |
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| Antibody Name |
undisclosed
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| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
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Antigen Info | ||||
| Payload Name |
Undisclosed
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| Therapeutic Target |
Stimulator of interferon genes protein (STING1)
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Target Info | ||||
| Linker Name |
Mc-Val-Cit-PABC
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 0.02 ug/mL | Positive HER expression (HER+++/++) | ||
| Method Description |
Cell viability was determined after incubation with compound JY201 or JY201b or control.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 0.6 ug/mL | Positive HER expression (HER+++/++) | ||
| Method Description |
Cell viability was determined after incubation with compound JY201 or JY201b or control.
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| In Vitro Model | Breast ductal carcinoma | JIMT-1 cells | CVCL_2077 | ||