Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ID: DRG0VLWXS)
ADC Name
anti-FOLR1-151-C-LOCK-D5
Synonyms
151-C-LOCK-D5; ADC-1
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Organization
SORRENTO THERAPEUTICS, INC.
Drug Status
Investigative
Drug-to-Antibody Ratio
4
Antibody Name
Undisclosed
Antigen Name
Folate receptor alpha (FOLR1)
  Antigen Info 
Payload Name
Undisclosed
Linker Name
Undisclosed
Conjugate Type
site-specific conjugation
General Information of The Activity Data Related to This ADC
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 3 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Tumor Growth lnhibition value (TGl) 
95.31
%
Undisclosed Undisclosed
Tumor Growth lnhibition value (TGl) 
100
%
Undisclosed Undisclosed
Tumor Growth lnhibition value (TGl) 
100
%
Undisclosed Undisclosed
Revealed Based on the Cell Line Data
Click To Hide/Show 2 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal inhibitory Concentration (lC50) 
0.35
nM
CVCL_1304
Endometrioid carcinoma of ovary, Ovarian endometrioid adenocarcinoma
Half Maximal inhibitory Concentration (lC50) 
45
nM
CVCL_0532
Ovarian serous adenocarcinoma
Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 3 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth lnhibition value (TGl)
95.31%
Method Description
Discovered Using Cell Line-derived IGROV1 tumor xenograft model in 151-C-LOCK-D5 1.5 mg/kg.
In Vivo Model IGROV1 tumor xenograft model
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth lnhibition value (TGl)
100%
Method Description
Discovered Using Cell Line-derived IGROV1 tumor xenograft model in 151-C-LOCK-D5 1.5 mg/kg.
In Vivo Model IGROV1 tumor xenograft model
Experiment 3 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth lnhibition value (TGl)
100%
Method Description
Discovered Using Cell Line-derived IGROV1 tumor xenograft model in 151-C-LOCK-D5 1.5 mg/kg.
In Vivo Model IGROV1 tumor xenograft model
Revealed Based on the Cell Line Data
Click To Hide/Show 2 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) 0.35 nM High IGROV1 expression (IGROV1 +++)
Method Description
IC50 Values (nM) of anti-FOLR1-151-C-LOCK-D5 and their corresponding controls in Human Tumor Cells IGROV1
In Vitro Model Endometrioid carcinoma of ovary, Ovarian endometrioid adenocarcinoma IGROV1 cells CVCL_1304
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) 45 nM Low SKOV-3 expression ( SKOV-3+)
Method Description
IC50 Values (nM) of anti-FOLR1-151-C-LOCK-D5 and their corresponding controls in Human Tumor Cells SKOV-3
In Vitro Model Ovarian serous adenocarcinoma SKOV-3 cells CVCL_0532
References
Ref 1 Antibody-drug conjugates comprising an anti-FOLR1 antibody