Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0VLWXS
ADC Name
anti-FOLR1-151-C-LOCK-D5
Synonyms
151-C-LOCK-D5; ADC-1
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Organization
SORRENTO THERAPEUTICS, INC.
Drug Status
Investigative
Drug-to-Antibody Ratio
4
Structure
Antibody Name
undisclosed
Antigen Name
Folate receptor alpha (FOLR1)
  Antigen Info 
Payload Name
Undisclosed
Therapeutic Target
Stimulator of interferon genes protein (STING1)
  Target Info 
Linker Name
Undisclosed
Conjugate Type
site-specific conjugation
General Information of The Activity Data Related to This ADC
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 3 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Tumor Growth lnhibition value (TGl) 
95.31
%
Undisclosed Undisclosed
Tumor Growth lnhibition value (TGl) 
100
%
Undisclosed Undisclosed
Tumor Growth lnhibition value (TGl) 
100
%
Undisclosed Undisclosed
Revealed Based on the Cell Line Data
Click To Hide/Show 2 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal inhibitory Concentration (lC50) 
0.35
nM
CVCL_1304
Endometrioid carcinoma of ovary, Ovarian endometrioid adenocarcinoma
Half Maximal inhibitory Concentration (lC50) 
45
nM
CVCL_0532
Ovarian serous adenocarcinoma
Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 3 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth lnhibition value (TGl)
95.31%
Method Description
Discovered Using Cell Line-derived IGROV1 tumor xenograft model in 151-C-LOCK-D5 1.5 mg/kg.
In Vivo Model IGROV1 tumor xenograft model
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth lnhibition value (TGl)
100%
Method Description
Discovered Using Cell Line-derived IGROV1 tumor xenograft model in 151-C-LOCK-D5 1.5 mg/kg.
In Vivo Model IGROV1 tumor xenograft model
Experiment 3 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth lnhibition value (TGl)
100%
Method Description
Discovered Using Cell Line-derived IGROV1 tumor xenograft model in 151-C-LOCK-D5 1.5 mg/kg.
In Vivo Model IGROV1 tumor xenograft model
Revealed Based on the Cell Line Data
Click To Hide/Show 2 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) 0.35 nM High IGROV1 expression (IGROV1 +++)
Method Description
IC50 Values (nM) of anti-FOLR1-151-C-LOCK-D5 and their corresponding controls in Human Tumor Cells IGROV1
In Vitro Model Endometrioid carcinoma of ovary, Ovarian endometrioid adenocarcinoma IGROV1 cells CVCL_1304
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) 45 nM Low SKOV-3 expression ( SKOV-3+)
Method Description
IC50 Values (nM) of anti-FOLR1-151-C-LOCK-D5 and their corresponding controls in Human Tumor Cells SKOV-3
In Vitro Model Ovarian serous adenocarcinoma SKOV-3 cells CVCL_0532
References
Ref 1 Antibody-drug conjugates comprising an anti-FOLR1 antibody