Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0VIZJR
ADC Name
IMAB362-DM4
Synonyms
IMAB362-DM4
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Organization
ASTELLAS PHARMA INC.
Drug Status
Investigative
Drug-to-Antibody Ratio
3.2
Antibody Name
IMAB362
  Antibody Info 
Antigen Name
Claudin-18.2 (CLDN18.2)
  Antigen Info 
Payload Name
Undisclosed
  Payload Info 
Linker Name
Undisclosed
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Click To Hide/Show 6 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal Effective Concentration (EC50) 
155
ng/ml
CVCL_3082
Gastric adenocarcinoma
Half Maximal Effective Concentration (EC50) 
372
ng/ml
CVCL_3082
Gastric adenocarcinoma
Half Maximal Effective Concentration (EC50) 
2600
ng/ml
CVCL_3082
Gastric adenocarcinoma
Half Maximal Effective Concentration (EC50) 
3046
ng/ml
CVCL_3082
Gastric adenocarcinoma
Half Maximal Effective Concentration (EC50) 
3909
ng/ml
CVCL_3082
Gastric adenocarcinoma
Half Maximal Effective Concentration (EC50) 
7487
ng/ml
CVCL_3082
Gastric adenocarcinoma
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
Click To Hide/Show 6 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC
Efficacy Data Half Maximal Effective Concentration (EC50) 155 ng/ml High CLDN18.2 expression (CLDN18.2 +++)
Method Description
A Cell line test on NUGC-4 10cF7-5 sort 3A
In Vitro Model Gastric adenocarcinoma NUGC-4 10cF7-5 sort 3a cells CVCL_3082
Experiment 2 Reporting the Activity Date of This ADC
Efficacy Data Half Maximal Effective Concentration (EC50) 372 ng/ml High CLDN18.2 expression (CLDN18.2 +++)
Method Description
A Cell line test on NUGC-4 10cE8
In Vitro Model Gastric adenocarcinoma NUGC-4 10cE8 cells CVCL_3082
Experiment 3 Reporting the Activity Date of This ADC
Efficacy Data Half Maximal Effective Concentration (EC50) 2600 ng/ml High CLDN18.2 expression (CLDN18.2 +++)
Method Description
A Cell line test on NUGC-4 10cF7-5 so1t 33
In Vitro Model Gastric adenocarcinoma NUGC-4 10cF7-5 so1t 33 cells CVCL_3082
Experiment 4 Reporting the Activity Date of This ADC
Efficacy Data Half Maximal Effective Concentration (EC50) 3046 ng/ml High CLDN18.2 expression (CLDN18.2 +++)
Method Description
A Cell line test on NUGC-4 10cE8
In Vitro Model Gastric adenocarcinoma NUGC-4 10cE8 cells CVCL_3082
Experiment 5 Reporting the Activity Date of This ADC
Efficacy Data Half Maximal Effective Concentration (EC50) 3909 ng/ml High CLDN18.2 expression (CLDN18.2 +++)
Method Description
A Cell line test on NUGC-4 10cF7-5 so1t 33
In Vitro Model Gastric adenocarcinoma NUGC-4 10cF7-5 so1t 33 cells CVCL_3082
Experiment 6 Reporting the Activity Date of This ADC
Efficacy Data Half Maximal Effective Concentration (EC50) 7487 ng/ml High CLDN18.2 expression (CLDN18.2 +++)
Method Description
A Cell line test on NUGC-4 10cE8
In Vitro Model Gastric adenocarcinoma NUGC-4 10cE8 cells CVCL_3082