Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)

ADC ID	DRG0VEIHB
ADC Name	MORAb-003 ADC4
Synonyms	MORAb-003 ADC4 Click to Show/Hide
Organization	EISAI R&D MANAGEMENT CO., LTD.
Drug Status	Investigative
Drug-to-Antibody Ratio	3.4
Structure
	3D MOL	2D MOL
Antibody Name	MORAb-003		Antibody Info
Antigen Name	Folate receptor alpha (FOLR1)		Antigen Info
Payload Name	Nostocyclopeptide-2		Payload Info
Linker Name	VCP linker		Linker Info
Conjugate Type	Cysteine-maleimide conjugation
Combination Type	VCP-Nostocyclopeptide

General Information of The Activity Data Related to This ADC

Revealed Based on the Cell Line Data

Click To Hide/Show 1 Activity Data Related to This Level

Standard Type	Value	Units	Cell Line	Disease Model
Half Maximal inhibitory Concentration (lC50)	3-100	nM	CVCL_1697	Osteosarcoma

Full List of Activity Data of This Antibody-drug Conjugate

Revealed Based on the Cell Line Data

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal inhibitory Concentration (lC50)	3-100 nM	High FRA expression (FRA +++)
Method Description	Use crystal violet analysis to evaluate the in vitro efficacy of the prepared ADCs. Initially screen all MORAb003 ADCs on IGROV1 (FRi (+++)) and SJSA - 1 (FReg (-)) cells.
In Vitro Model	Osteosarcoma	SJSA-1 cells		CVCL_1697

References

Ref 1	Fan bracket