Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)

ADC ID	DRG0TPWBF
ADC Name	WO2018135501A1 ADC-2
Synonyms	WO2018135501A1 ADC2 Click to Show/Hide
Organization	Daiichi Sankyo Co., Ltd.
Drug Status	Investigative
Indication	In total 1 Indication(s) Gastrointestinal stromal tumor [ICD11:2B5B] Investigative
Drug-to-Antibody Ratio	5.6
	3D MOL	2D MOL
Antibody Name	04-046Ch		Antibody Info
Antigen Name	G-protein coupled receptor 20 (GPR20)		Antigen Info
Payload Name	Undisclosed
Linker Name	WO2018135501A1_ADC-2 linker

General Information of The Activity Data Related to This ADC

Discovered Using Patient-derived Xenograft Model

Click To Hide/Show 2 Activity Data Related to This Level

Standard Type	Value	Units	Animal Model (No. of PDX)
Tumor Growth Inhibition value (TGI)	≉ 33.3	%	Gastrointestinal stromal tumor (GIST) PDX model (PDX: GIST-T1/GPR20)
Tumor Growth Inhibition value (TGI)	≋ 87	%	Gastrointestinal stromal tumor (GIST) PDX model (PDX: GIST430)

Full List of Activity Data of This Antibody-drug Conjugate

Discovered Using Patient-derived Xenograft Model

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC				[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≉ 33.30% (Day 46)	Positive GPR20 expression (GPR20+++/++)
Method Description	To establish gastrointestinal stromal tumor model, 5 x 10⁶ cells were implanted into the right flank of athymic nu/nu female donor mice. When tumors reached ~100 mm³ mice were randomly allocated to treatment groups. The dose of ADC was 10 mg/kg, i.v.*1.
In Vivo Model	Gastrointestinal stromal tumor (GIST) PDX model (PDX: GIST-T1/GPR20)
Experiment 2 Reporting the Activity Date of This ADC				[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≋ 87.00% (Day 52)	Positive GPR20 expression (GPR20+++/++)
Method Description	To establish gastrointestinal stromal tumor model, 5 x 10⁶ cells were implanted into the right flank of athymic nu/nu female donor mice. When tumors reached ~100 mm³ mice were randomly allocated to treatment groups. The dose of ADC was 10 mg/kg, qw*3.
In Vivo Model	Gastrointestinal stromal tumor (GIST) PDX model (PDX: GIST430)

References

Ref 1	Anti-gpr20 antibody and anti-gpr20 antibody-drug conjugate; 2018-07-26.