Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)

ADC ID	DRG0TELNA
ADC Name	PSMA-HC41-LD4
Synonyms	PSMA-HC41-LD4 Click to Show/Hide
Organization	BYONDIS B.V.
Drug Status	Investigative
Drug-to-Antibody Ratio	1.6
Structure
Antibody Name	Anti-PSMA-HC41	Antibody Info
Antigen Name	Glutamate carboxypeptidase 2 (FOLH1)	Antigen Info
Payload Name	Undisclosed
Therapeutic Target	Stimulator of interferon genes protein (STING1)	Target Info
Linker Name	Undisclosed

General Information of The Activity Data Related to This ADC

Revealed Based on the Cell Line Data

Click To Hide/Show 1 Activity Data Related to This Level

Standard Type	Value	Units	Cell Line	Disease Model
Half Maximal inhibitory Concentration (lC50)	0.48	nM	CVCL_4782	Prostate carcinoma

Full List of Activity Data of This Antibody-drug Conjugate

Revealed Based on the Cell Line Data

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal inhibitory Concentration (lC50)	0.48 nM	Positive PSMA expression (PSMA +++/++)
Method Description	In vitro cytotoxicity of anti-PSMA ADCs in human tumour cells expressing PSMAPSMA-positive cell line LNCaP-C4.2
In Vitro Model	Prostate carcinoma	LNCaP-C4.2 cells		CVCL_4782

References

Ref 1	Non-linear self-immolative linkers and conjugates thereof