Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0SQBPH
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| ADC Name |
CMPXC
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| Synonyms |
CMPXC
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| Organization |
The Catholic University of Korea.; Northwestern University.
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| Drug Status |
Investigative
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| Structure |
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| Antibody Name |
Cetuximab
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Antibody Info | ||||
| Antigen Name |
Epidermal growth factor receptor (EGFR)
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Antigen Info | ||||
| Payload Name |
Chlorin e6 (Ce6)
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Payload Info | ||||
| Linker Name |
Mal-PX linker
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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General Information of The ADMET Data Related to This ADC(2027 Update)
Absorption
| Standard Type | Value | Units | Description | Reference |
|---|---|---|---|---|
| Area Under the Concentration-Time Curve (AUC) | 5±0.15 | mg*h/L |
Pharmacokinetic parameters of mice after IV injection of CMPXC.
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[1] |
| Maximum Observed Concentration (Cmax) | 1.45±0.6 | mg/L |
Pharmacokinetic parameters of mice after IV injection of CMPXC.
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[1] |
Distribution
| Standard Type | Value | Units | Description | Reference |
|---|---|---|---|---|
| Area Under the Concentration-Time Curve (AUC) | 5±0.15 | mg*h/L |
Pharmacokinetic parameters of mice after IV injection of CMPXC.
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[1] |
Metabolism
| Standard Type | Value | Units | Description | Reference |
|---|---|---|---|---|
| Area Under the Concentration-Time Curve (AUC) | 5±0.15 | mg*h/L |
Pharmacokinetic parameters of mice after IV injection of CMPXC.
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[1] |
Excretion
| Standard Type | Value | Units | Description | Reference |
|---|---|---|---|---|
| Area Under the Concentration-Time Curve (AUC) | 5±0.15 | mg*h/L |
Pharmacokinetic parameters of mice after IV injection of CMPXC.
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[1] |
| Elimination Half-Life (t1/2) | 0.63±0.43 | h |
Pharmacokinetic parameters of mice after IV injection of CMPXC.
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[1] |
References