Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0RWCYL
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| ADC Name |
ABC-1C
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| Synonyms |
ABC 1C
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| Drug Status |
Investigative
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| Indication |
In total 1 Indication(s)
Escherichia coli infection [ICD11:1A03]
Investigative
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| Drug-to-Antibody Ratio |
2
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| Antibody Name |
Targeted against E. coli mAb (hWN1)
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Antibody Info | ||||
| Antigen Name |
Epidermal growth factor receptor (EGFR); Receptor tyrosine-protein kinase erbB-3 (ERBB3)
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Antigen Info | ||||
| Payload Name |
Macrocyclic antimicrobial peptide 1C (AMP-1C)
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Payload Info | ||||
| Linker Name |
Undisclosed
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| Conjugate Type |
Site-specific conjugation through the Sortase A.
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
10.00 nM
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| Method Description |
Bacterial killing potencies and hemolytic activities of prepared ABCs. MKC 50 represents the minimal concentration to impart >50 % killing.
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| In Vitro Model | . | Escherichia coli 2 (E. coli 2) | . | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
130 nM
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| Method Description |
Bacterial killing potencies and hemolytic activities of prepared ABCs. MKC 50 represents the minimal concentration to impart >50 % killing.
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| In Vitro Model | . | Escherichia coli 1 (E. coli 1) | . | ||
References
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