Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0RQUJK
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| ADC Name |
Trastuzumab-C-8
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| Synonyms |
Trastuzumab-C-8
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| Organization |
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
3.56
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| Structure |
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| Antibody Name |
Trastuzumab
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Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
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Antigen Info | ||||
| Payload Name |
KR1020250002133A Trastuzumab-C-8 Payload
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Payload Info | ||||
| Linker Name |
KR1020250002133A Trastuzumab-C-8 Linker
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Linker Info | ||||
| Conjugate Type |
site-specific conjugation
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General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 0.112 nM | High HER2 expression (HER2 +++) | ||
| Method Description |
Trastuzumab-C-8 was tested in HCC1954,80ul,18ᆬh
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| In Vitro Model | Breast ductal carcinoma | HCC1954 cells | CVCL_1259 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 0.25 nM | High HER2 expression (HER2 +++) | ||
| Method Description |
Trastuzumab-C-8 was tested in NCI-N87,80ul,18ᆬh
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| In Vitro Model | Gastric tubular adenocarcinoma | NCI-N87 cells | CVCL_1603 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 374.766 nM | High HER2 expression (HER2 +++) | ||
| Method Description |
Trastuzumab-C-8 was tested in NCI-H358,80ul,18ᆬh
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| In Vitro Model | Minimally invasive lung adenocarcinoma | NCI-H358 cells | CVCL_1559 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 17.72 nM | High HER2 expression (HER3 +++) | ||
| Method Description |
Trastuzumab-C-8 was tested in HCC1954 and PBMC,50ul,24h
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| In Vitro Model | Breast ductal carcinoma | HCC1954 cells | CVCL_1259 | ||
| Experiment 5 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Emax (TNF-a) | 1836.92 pg/mL | High HER2 expression (HER4 +++) | ||
| Method Description |
Trastuzumab-C-8 was tested in HCC1954 and PBMC,50ul,24h
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| In Vitro Model | Breast ductal carcinoma | HCC1954 cells | CVCL_1259 | ||