Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0QEKUX
ADC Name
CN115429893A ADC17
Synonyms
CN115429893A ADC17
   Click to Show/Hide
Organization
Bio Thera Solutions Ltd
Drug Status
Investigative
Drug-to-Antibody Ratio
4
Structure
Antibody Name
undisclosed
Antigen Name
Folate receptor alpha (FOLR1)
  Antigen Info 
Payload Name
CN115429893A ADC1 Payload
  Payload Info 
Linker Name
CB07 linker
  Linker Info 
General Information of The Activity Data Related to This ADC
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 2 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Tumor Growth lnhibition value (TGl) 
71.59
%
Undisclosed Undisclosed
Tumor Growth lnhibition value (TGl) 
71.59
%
Undisclosed Undisclosed
Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 2 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth lnhibition value (TGl) 71.59% Positive FR-alpha expression (FR-alpha+++/++)
Method Description
In the OV3756 xenograft model, the ADCs were administered at 5 mg/kg (once, IV).
In Vivo Model OV3756 xenograft model
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth lnhibition value (TGl) 71.59% Positive FR-alpha expression (FR-alpha+++/++)
Method Description
In the OV3756 xenograft model, the ADCs were administered at 5 mg/kg (once, IV).
In Vivo Model OV3756 xenograft model
References
Ref 1 Drug conjugates and uses thereof