Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ID: DRG0OQXQI)
ADC Name
P2-528mAb
Synonyms
P2-528mAb
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Organization
Commonwealth Scientific and Industrial Research Organization; University of Queensland.
Drug Status
Investigative
Drug-to-Antibody Ratio
1
Antibody Name
528mAb
  Antibody Info 
Antigen Name
Epidermal growth factor receptor (EGFR)
  Antigen Info 
Payload Name
Undisclosed
Linker Name
Undisclosed
Conjugate Type
Random conjugation through nucleophilic lysines.
2027 Update
ADC-specific functional property
Binding Affinity
Click To Hide/Show 1 ADC-specific functional property Data
Dissocation Constant (Kd) Binding Target Description Reference
3.0±0.1 nM
EGFR
Surface plasmon resonance (SPR)
[1]
References
Ref 1 RAFT Polymer-Antibody Conjugation: Squaramide Ester Chemistry Leads to Conjugates with a Therapeutic Anti-EGFR Antibody with Full Retention of Activity and Increased Tumor Uptake In Vivo