Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ID: DRG0LRWGJ)
| ADC Name |
US20230256114A1 ADC (DAR2.8)
|
|||||
|---|---|---|---|---|---|---|
| Synonyms |
US20230256114A1 ADC (DAR2.8)
Click to Show/Hide
|
|||||
| Organization |
BIONECURE THERAPEUTICS, INC.
|
|||||
| Drug Status |
Investigative
|
|||||
| Drug-to-Antibody Ratio |
2.8
|
|||||
| Antibody Name |
Anti-Trop
|
Antibody Info | ||||
| Antigen Name |
Tumor-associated calcium signal transducer 2 (TACSTD2)
|
Antigen Info | ||||
| Payload Name |
Undisclosed
|
|||||
| Linker Name |
Undisclosed
|
|||||
General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 0.38 nM | High TROP2 expression (TROP2 +++) | ||
| Method Description |
Table 3 summarizes the results from in vitro cytotoxicity assays in which ADCs containing various DM1 derivative payload at different DARs were tested.
|
||||
| In Vitro Model | Pancreatic ductal adenocarcinoma | BxPC-3 cells | CVCL_0186 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 17.56 nM | Positive TROP2 expression (TROP2+++/++) | ||
| Method Description |
Table 3 summarizes the results from in vitro cytotoxicity assays in which ADCs containing various DM1 derivative payload at different DARs were tested.
|
||||
| In Vitro Model | Gastric tubular adenocarcinoma | NCI-N87 cells | CVCL_1603 | ||