Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0IKZUY
|
|||||
|---|---|---|---|---|---|---|
| ADC Name |
JY201
|
|||||
| Synonyms |
JY201
Click to Show/Hide
|
|||||
| Organization |
SHENZHEN ENDURING BIOTECH, LTD.
|
|||||
| Drug Status |
Investigative
|
|||||
| Structure |
|
|||||
| Antibody Name |
undisclosed
|
|||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
|
Antigen Info | ||||
| Payload Name |
Undisclosed
|
|||||
| Therapeutic Target |
Stimulator of interferon genes protein (STING1)
|
Target Info | ||||
| Linker Name |
Mc-Val-Cit-PABC
|
Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
|
|||||
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 2.23 nM | Positive HER expression (HER+++/++) | ||
| Method Description |
Cell viability was determined after incubation with compound JY201 or JY201b or control.
|
||||
| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 75.55 nM | Low HER2 expression (HER2+) | ||
| Method Description |
Cell viability was determined after incubation with compound JY201 or JY201b or control.
|
||||
| In Vitro Model | Lung adenocarcinoma | HCC-827 cells | CVCL_2063 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 3.29 ug/mL | Positive HER expression (HER+++/++) | ||
| Method Description |
Cell viability was determined after incubation with compound JY201 or JY201b or control.
|
||||
| In Vitro Model | Breast ductal carcinoma | JIMT-1 cells | CVCL_2077 | ||