Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0HYYJO
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| ADC Name |
US12144865B2 5a
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| Synonyms |
US12144865B2 5a
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| Organization |
BAYER PHARMA AKTIENGESELLSCHAFT
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
2.4
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| Structure |
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| Antibody Name |
Cetuximab
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Antibody Info | ||||
| Antigen Name |
Epidermal growth factor receptor (EGFR)
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Antigen Info | ||||
| Payload Name |
Undisclosed
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| Therapeutic Target |
Stimulator of interferon genes protein (STING1)
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Target Info | ||||
| Linker Name |
Undisclosed
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| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50)Human PBMC | 0.603 nM | Positive EGFR expression (EGFR+++/++) | ||
| Method Description |
Tables 1b and 1c below set out the IC50 values for representative working examples from this assay
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| In Vitro Model | Lung mucoepidermoid carcinoma | NCI-H292 cells | CVCL_0455 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50)Human PBMC | 500 nM | Positive EGFR expression (EGFR+++/++) | ||
| Method Description |
Tables 1b and 1c below set out the IC50 values for representative working examples from this assay
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| In Vitro Model | Liver and intrahepatic bile duct epithelial neoplasm | SK-HEP-1 cells | CVCL_0525 | ||