Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0GNFXY
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| ADC Name |
AU2020291014A1 IC-15
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| Synonyms |
IC-15
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| Organization |
BOLT BIOTHERAPEUTICS, INC.
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
2.85
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| Structure |
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| Antibody Name |
Avelumab
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Antibody Info | ||||
| Antigen Name |
Programmed cell death 1 ligand 1 (CD274)
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Antigen Info | ||||
| Payload Name |
Undisclosed
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| Therapeutic Target |
Stimulator of interferon genes protein (STING1)
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Target Info | ||||
| Linker Name |
Undisclosed
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| Conjugate Type |
Random conjugation through nucleophilic lysines
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| Combination Type |
BzL-21
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
199.5 nM
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| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||