Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0FQDZV
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|---|---|---|---|---|---|---|
| ADC Name |
37486969 ADC 37
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| Synonyms |
ADC 37
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| Organization |
Mersana Therapeutics, Inc.; 3-Dimensional Consulting.
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
8
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| Structure |
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| Antibody Name |
Trastuzumab
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Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
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Antigen Info | ||||
| Payload Name |
STING Agonist 6
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Payload Info | ||||
| Linker Name |
Undisclosed
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| Conjugate Type |
Site-specific bioconjugation at Trastuzumab-Lys248-thiol
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General Information of The ADMET Data Related to This ADC(2027 Update)
Absorption
| Standard Type | Value | Units | Description | Reference |
|---|---|---|---|---|
| Area Under the Concentration-Time Curve (AUC) | 899 | day*ng/mL |
In vivo mouse plasma PK analysis for the conjugated drug of ADC, AUCinf.
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[1] |
Distribution
| Standard Type | Value | Units | Description | Reference |
|---|---|---|---|---|
| Area Under the Concentration-Time Curve (AUC) | 899 | day*ng/mL |
In vivo mouse plasma PK analysis for the conjugated drug of ADC, AUCinf.
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[1] |
Metabolism
| Standard Type | Value | Units | Description | Reference |
|---|---|---|---|---|
| Area Under the Concentration-Time Curve (AUC) | 899 | day*ng/mL |
In vivo mouse plasma PK analysis for the conjugated drug of ADC, AUCinf.
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[1] |
Excretion
| Standard Type | Value | Units | Description | Reference |
|---|---|---|---|---|
| Clearance (CL) | 36.8 | mL/day/kg |
In vivo mouse plasma PK analysis for the conjugated drug of ADC.
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[1] |
| Area Under the Concentration-Time Curve (AUC) | 899 | day*ng/mL |
In vivo mouse plasma PK analysis for the conjugated drug of ADC, AUCinf.
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[1] |
References