Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0FNAHA
ADC Name
Isumab01-C1a
Synonyms
lsumab01-C1a
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Organization
MURGITROYD & COMPANY
Drug Status
Investigative
Drug-to-Antibody Ratio
1.7
Antibody Name
Undisclosed
Antigen Name
Folate receptor alpha (FOLR1)
  Antigen Info 
Payload Name
Undisclosed
Therapeutic Target
Stimulator of interferon genes protein (STING1)
  Target Info 
Linker Name
Undisclosed
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Click To Hide/Show 4 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal inhibitory Concentration (lC50) 
0.174
pM
CVCL_0363
Gestational choriocarcinoma
Half Maximal inhibitory Concentration (lC50) 
11
pM
CVCL_1530
Lung non-small cell carcinoma
Half Maximal inhibitory Concentration (lC50) 
50
pM
CVCL_0465
Ovarian serous adenocarcinoma
Half Maximal inhibitory Concentration (lC50) 
398
pM
CVCL_3768
Adenocarcinoma of ovary, Ovarian adenocarcinoma
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
Click To Hide/Show 4 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) 0.174 pM High FRa expression (FRa +++)
Method Description
A Cell line test on Jeg3
In Vitro Model Gestational choriocarcinoma Jeg3 cells CVCL_0363
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) 11 pM High FRa expression (FRa +++)
Method Description
A Cell line test on H2110
In Vitro Model Lung non-small cell carcinoma H2110 cells CVCL_1530
Experiment 3 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) 50 pM High FRa expression (FRa +++)
Method Description
A Cell line test on OVCAR-3
In Vitro Model Ovarian serous adenocarcinoma OVCAR-3 cells CVCL_0465
Experiment 4 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) 398 pM High FRa expression (FRa +++)
Method Description
A Cell line test on OV90
In Vitro Model Adenocarcinoma of ovary, Ovarian adenocarcinoma OV90 cells CVCL_3768
References
Ref 1 Antibody-drug conjugate compounds, and methods of use and treatment