Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0ESMLO
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| ADC Name |
WO2018135501A1 ADC-14
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| Synonyms |
WO2018135501A1 ADC14
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| Organization |
Daiichi Sankyo Co., Ltd.
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| Drug Status |
Investigative
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| Indication |
In total 1 Indication(s)
Gastrointestinal stromal tumor [ICD11:2B5B]
Investigative
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| Drug-to-Antibody Ratio |
7.6
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| Antibody Name |
h046-H4e/L7
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Antibody Info | ||||
| Antigen Name |
G-protein coupled receptor 20 (GPR20)
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Antigen Info | ||||
| Payload Name |
Undisclosed
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| Linker Name |
WO2018135501A1_ADC-14 linker
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General Information of The Activity Data Related to This ADC
Discovered Using Patient-derived Xenograft Model
| Standard Type | Value | Units | Animal Model (No. of PDX) |
|---|---|---|---|
| Tumor Growth Inhibition value (TGI) |
≜ 33.8
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%
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Gastrointestinal stromal tumor (GIST) PDX model (PDX: GIST074)
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Discovered Using Cell Line-derived Xenograft Model
| Standard Type | Value | Units | Cell Line | Disease Model |
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| Tumor Growth Inhibition value (TGI) |
≛ 18.5
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%
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NCI-N87 cells
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Gastric tubular adenocarcinoma
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Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Patient-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≜ 33.80% (Day 26) | Positive GPR20 expression (GPR20+++/++) | ||
| Method Description |
To establish gastrointestinal stromal tumor model, 5 x 106 cells were implanted into the right flank of athymic nu/nu female donor mice. When tumors reached ~100 mm3 mice were randomly allocated to treatment groups. The dose of ADC was 10 mg/kg, i.v. at day29, day 50.
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| In Vivo Model | Gastrointestinal stromal tumor (GIST) PDX model (PDX: GIST074) | ||||
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≛ 18.50% (Day 26) | Positive GPR20 expression (GPR20+++/++) | ||
| Method Description |
To establish gastrointestinal stromal tumor model, 5 x 106 cells were implanted into the right flank of athymic nu/nu female donor mice. When tumors reached ~100 mm3 mice were randomly allocated to treatment groups. The dose of ADC was 3 mg/kg, i.v.*1.
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| In Vivo Model | NCI-N87 CDX model | ||||
| In Vitro Model | Gastric tubular adenocarcinoma | NCI-N87 cells | CVCL_1603 | ||
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