Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0ECBNB
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| ADC Name |
US20240166759A1 Antibody2-L1
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| Synonyms |
Antibody2-L1
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| Organization |
ANGIEX, INC.
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
2
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| Antibody Name |
undisclosed
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| Antigen Name |
Transmembrane 4 L6 family member 1 (TM4SF1)
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Antigen Info | ||||
| Payload Name |
Undisclosed
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| Therapeutic Target |
Stimulator of interferon genes protein (STING1)
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Target Info | ||||
| Linker Name |
Undisclosed
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| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 0.04 nM | Positive TM4SF1 expression (TM4SF1+++/++) | ||
| Method Description |
Cells were treated incubated for 4 days with the antibody drug conjugate before assessing cell viability on day 5.
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| In Vitro Model | Pancreatic undifferentiated carcinoma | MiaPaca2 cells | CVCL_0428 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 0.06 nM | Positive TM4SF1 expression (TM4SF1+++/++) | ||
| Method Description |
Cells were treated incubated for 4 days with the antibody drug conjugate before assessing cell viability on day 5.
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| In Vitro Model | Lung adenocarcinoma | A549 cells | CVCL_0023 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 0.1 nM | Positive TM4SF1 expression (TM4SF1+++/++) | ||
| Method Description |
Cells were treated incubated for 4 days with the antibody drug conjugate before assessing cell viability on day 5.
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| In Vitro Model | Normal | HUVEC cells | CVCL_9S75 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 0.81 nM | Positive TM4SF1 expression (TM4SF1+++/++) | ||
| Method Description |
Cells were treated incubated for 4 days with the antibody drug conjugate before assessing cell viability on day 5.
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| In Vitro Model | Ovarian serous adenocarcinoma | SKOV-3 cells | CVCL_0532 | ||
References