Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0DDUMC
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| ADC Name |
Tras (C2)-Cp
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| Synonyms |
Tras (C2)-Cp
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| Organization |
Technical University of Darmstadt.; University of Bielefeld.; Lantern Pharma Inc.; The University of Tennessee.; Technical University of Darmstadt.
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
1.5
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| Structure |
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| Antibody Name |
Trastuzumab (C2)
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Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
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Antigen Info | ||||
| Payload Name |
Cryptophycin-uD[Dap (Me)]
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Mc-Val-Cit-PABC
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Linker Info | ||||
| Conjugate Type |
Site-specific conjugation via re-bridging.
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ADC-specific functional property(2027 Update)
Binding Affinity
| Dissocation Constant (Kd) | Binding Target | Description | Reference |
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| 5 nM |
SK-BR-3 cells (HER2)
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EC50 values of the affinity of the ADCs binding to SK-BR-3 cells.
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[1]
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 59䔮 pM | Positive HER2 expression (HER2+++/++) | ||
| Method Description |
Proliferation assays revealed EC50 values in double-digit picomolar range for all constructs on high HER2 expressing cell line SK-BR-3 (Figure 3a, Table 2) which was found to be comparable or significantly lower than for Cp-bearing ADCs found in literature
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 1208𫔬 pM | Positive HER2 expression (HER2+++/++) | ||
| Method Description |
Proliferation assays revealed EC50 values in double-digit picomolar range for all constructs on high HER2 expressing cell line SK-BR-3 (Figure 3a, Table 2) which was found to be comparable or significantly lower than for Cp-bearing ADCs found in literature
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| In Vitro Model | Breast ductal carcinoma | JIMT-1 cells | CVCL_2077 | ||
References