Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0CEYRK
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| ADC Name |
KR1020250011922A ADC-S425 demasked
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| Synonyms |
KR1020250011922A ADC-S425 demasked
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| Organization |
BYONDIS B.V.
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| Drug Status |
Investigative
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| Antibody Name |
Tratuzumab (P41C)
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Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
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Antigen Info | ||||
| Payload Name |
Undisclosed
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| Therapeutic Target |
Stimulator of interferon genes protein (STING1)
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Target Info | ||||
| Linker Name |
Undisclosed
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 0.39 ug/ml | Positive HER2 expression (HER2+++/++) | ||
| Method Description |
ADCs were tested in HER2-positive SK-BR-3 cells and incubated for 6 days, then IC50 waa determined with CTG.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||