Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ID: DRG0CDBUM)
ADC Name
KR1020250011922A ADC-S424 masked
Synonyms
KR1020250011922A ADC-S424 masked
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Organization
BYONDIS B.V.
Drug Status
Investigative
Antibody Name
Tratuzumab (P41C)
  Antibody Info 
Antigen Name
Receptor tyrosine-protein kinase erbB-2 (HER2)
  Antigen Info 
Payload Name
Undisclosed
Linker Name
Undisclosed
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal Effective Concentration (EC50) 
14.43
ug/ml
CVCL_0033
Breast adenocarcinoma
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Effective Concentration (EC50) 14.43 ug/ml Positive HER2 expression (HER2+++/++)
Method Description
ADCs were tested in HER2-positive SK-BR-3 cells and incubated for 6 days, then IC50 waa determined with CTG.
In Vitro Model Breast adenocarcinoma SK-BR-3 cells CVCL_0033
References
Ref 1 New shielded antibody