Antibody-drug Conjugate Information | ADCdb

General Information of This Antibody-drug Conjugate (ADC)

ADC ID	DRG0BLDGI
ADC Name	P3-528mAb
Synonyms	P3-528mAb Click to Show/Hide
Organization	Commonwealth Scientific and Industrial Research Organization; University of Queensland.
Drug Status	Investigative
Drug-to-Antibody Ratio	1
Structure
Antibody Name	528mAb					Antibody Info
Antigen Name	Epidermal growth factor receptor (EGFR)					Antigen Info
Payload Name	Undisclosed
Therapeutic Target	Stimulator of interferon genes protein (STING1)					Target Info
Linker Name	Undisclosed
Conjugate Type	Random conjugation through nucleophilic lysines.

ADC-specific functional property(2027 Update)

Binding Affinity

Click To Hide/Show 1 ADC-specific functional property Data

Dissocation Constant (Kd)	Binding Target	Description	Reference
2.5±0.1 nM	EGFR	Surface plasmon resonance (SPR)	[1]

References

Ref 1	RAFT Polymer-Antibody Conjugation: Squaramide Ester Chemistry Leads to Conjugates with a Therapeutic Anti-EGFR Antibody with Full Retention of Activity and Increased Tumor Uptake In Vivo