Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0BCJEW
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| ADC Name |
US12144865B2 34te-4
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| Synonyms |
US12144865B2 34te-4
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| Organization |
BAYER PHARMA AKTIENGESELLSCHAFT
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
3.9
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| Structure |
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| Antibody Name |
Anti-TPP-7511
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Antibody Info | Antigen Name |
Undisclosed
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| Payload Name |
Undisclosed
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| Therapeutic Target |
Stimulator of interferon genes protein (STING1)
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Target Info | ||||
| Linker Name |
Undisclosed
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| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50)Human PBMC | 0.329 nM | Positive HER2 expression (HER2+++/++) | ||
| Method Description |
Tables 1b and 1c below set out the IC50 values for representative working examples from this assay
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| In Vitro Model | Breast inflammatory carcinoma | KPL4 cells | CVCL_5310 | ||