Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0AVJCO
ADC Name
AOC-1020
Synonyms
AOC 1020; AOC-FSHD; AOC1020
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Organization
Avidity Biosciences, Inc.
Drug Status
Phase 1/2
Indication
In total 1 Indication(s)
Facioscapulohumeral muscular dystrophy [ICD11:8C70]
Phase 2
Antibody Name
Undisclosed
Antigen Name
Double homeobox protein 4 (DUX4)
  Antigen Info 
Payload Name
DUX4 siRNA
  Payload Info 
Therapeutic Target
Double homeobox protein 4 (DUX4)
  Target Info 
Linker Name
Undisclosed
Special Approval(s)
Fast track(FDA); Orphan drug(FDA)
General Information of The Activity Data Related to This ADC
Identified from the Human Clinical Data
Click To Hide/Show 1 Activity Data Related to This Level
Standard Type NCT Number Clinical Status Clinical Trial Description
Undisclosed  NCT05747924
Phase 1
A randomized, double-blind, placebo-controlled, phase 1/2 study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of AOC 1020 administered intravenously to adult participants with facioscapulohumeral muscular dystrophy (FSHD).

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Full List of Activity Data of This Antibody-drug Conjugate
Identified from the Human Clinical Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Related Clinical Trial
NCT Number NCT05747924  Clinical Status Phase 1
Clinical Description A randomized, double-blind, placebo-controlled, phase 1/2 study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of AOC 1020 administered intravenously to adult participants with facioscapulohumeral muscular dystrophy (FSHD).
References
Ref 1 A Randomized, Double-blind, Placebo-controlled, Phase 1/2 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Exploratory Efficacy of AOC 1020 Administered Intravenously to Adult Participants With Facioscapulohumeral Muscular Dystrophy (FSHD), NCT05747924

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