Antigen Information

General Information of This Antigen
Antigen ID
TAR0UJYSQ
Antigen Name
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1)
Gene Name
ENTPD1
Synonym
CD39
Sequence
MEDTKESNVKTFCSKNILAILGFSSIIAVIALLAVGLTQNKALPENVKYGIVLDAGSSHT
SLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQ
HQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWI
TINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFR
LYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTP
CTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAF
SAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYIL
SLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHSTYVFL
MVLFSLVLFTVAIIGLLIFHKPSYFWKDMV

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Family
GDA1/CD39 NTPase family
Function
FUNCTION: Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides (Probable) (PubMed:8529670, PubMed:8626624, PubMed:8955160, PubMed:8996251). By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow (PubMed:8955160, PubMed:8996251). {ECO:0000269|PubMed:8529670, ECO:0000269|PubMed:8626624, ECO:0000269|PubMed:8955160, ECO:0000269|PubMed:8996251, ECO:0000305|PubMed:10636909}.

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Uniprot Entry
ENTP1_HUMAN
HGNC ID
HGNC:3363 ,
KEGG ID
hsa:953 ,
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
f1-SMCC-DM1
Mertansine DM1
Undisclosed
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
f314-MC-VC-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [1]
 ADC Info 
f314-MC-MMAF
Undisclosed
Undisclosed
Undisclosed
 [1]
 ADC Info 
f314-SMCC-DM1
Mertansine DM1
Undisclosed
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [1]
 ADC Info 
f314-SPDB-DM4
Undisclosed
Undisclosed
Undisclosed
 [1]
 ADC Info 
f314-C4-VC-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
C4-VC-PAB
 [1]
 ADC Info 
f314-C5-VC-PAB-MMAE-0.8
Monomethyl auristatin E
Microtubule (MT)
C5-VC-PAB
 [1]
 ADC Info 
f314-C5-VC-PAB-MMAE-1.8
Monomethyl auristatin E
Microtubule (MT)
C5-VC-PAB
 [1]
 ADC Info 
f314-C5-VC-PAB-MMAE-2.3
Monomethyl auristatin E
Microtubule (MT)
C5-VC-PAB
 [1]
 ADC Info 
f314-C5-VC-PAB-MMAE-3.0
Monomethyl auristatin E
Microtubule (MT)
C5-VC-PAB
 [1]
 ADC Info 
f314-C6-VC-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
C6-VC-PAB
 [1]
References
Ref 1 Anti-CD39 antibody-drug conjugate and use thereof