Antigen Information
General Information of This Antigen (ID: TAR0UJYSQ)
| Antigen Name | Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) |
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| Gene Name | ENTPD1 |
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| Gene ID | ||||||
| Synonym | CD39 |
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| Sequence |
MEDTKESNVKTFCSKNILAILGFSSIIAVIALLAVGLTQNKALPENVKYGIVLDAGSSHT
SLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQ HQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWI TINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFR LYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTP CTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAF SAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYIL SLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHSTYVFL MVLFSLVLFTVAIIGLLIFHKPSYFWKDMV Click to Show/Hide
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| Family | GDA1/CD39 NTPase family |
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| Function |
FUNCTION: Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides (Probable) (PubMed:8529670, PubMed:8626624, PubMed:8955160, PubMed:8996251). By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow (PubMed:8955160, PubMed:8996251). {ECO:0000269|PubMed:8529670, ECO:0000269|PubMed:8626624, ECO:0000269|PubMed:8955160, ECO:0000269|PubMed:8996251, ECO:0000305|PubMed:10636909}.
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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
|---|---|---|---|---|
F1
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
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F1-SMCC-DM1
[1]
|
Mertansine DM1 |
Microtubule (MT) |
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
F314
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
F314-MC-VC-PAB-MMAE
[1]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
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F314-MC-MMAF
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
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F314-SMCC-DM1
[1]
|
Mertansine DM1 |
Microtubule (MT) |
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
|
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F314-SPDB-DM4
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
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F314-C4-VC-PAB-MMAE
[1]
|
Monomethyl auristatin E |
Microtubule (MT) |
C4-VC-PAB |
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F314-C5-VC-PAB-MMAE-0.8
[1]
|
Monomethyl auristatin E |
Microtubule (MT) |
C5-VC-PAB |
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F314-C5-VC-PAB-MMAE-1.8
[1]
|
Monomethyl auristatin E |
Microtubule (MT) |
C5-VC-PAB |
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F314-C5-VC-PAB-MMAE-2.3
[1]
|
Monomethyl auristatin E |
Microtubule (MT) |
C5-VC-PAB |
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F314-C5-VC-PAB-MMAE-3.0
[1]
|
Monomethyl auristatin E |
Microtubule (MT) |
C5-VC-PAB |
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|
F314-C6-VC-PAB-MMAE
[1]
|
Monomethyl auristatin E |
Microtubule (MT) |
C6-VC-PAB |