Antigen Information

General Information of This Antigen
Antigen ID
TAR0RBHCF
Antigen Name
Globo H (globotriaosylceramide)
Function
Globo H (globotriaosylceramide) is a global-series glycosphingolipid antigen that is present on the outer membrane of some cancer cells. Globo H is not expressed in normal tissue cells but is expressed in a number of types of cancers, including cancers of the breast, prostate, and pancreas. Globo H's exclusivity for cancer cells makes it a target of interest for cancer therapies.

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Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
OBI-999
Monomethyl auristatin E
Microtubule (MT)
ThioBridge-PEG24-Val-Cit-PABC
 [1]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Globo-H ADC
Undisclosed
Undisclosed
Undisclosed
 [2]
References
Ref 1 Preclinical Studies of OBI-999: A Novel Globo H-Targeting Antibody-Drug Conjugate. Mol Cancer Ther. 2021 Jun;20(6):1121-1132.
Ref 2 Anti-Globo H ADC against cancer; institute of pharmaceutics development center for biotechnology; 2020