Antigen Information
General Information of This Antigen (ID: TAR0QEGHL)
| Antigen Name | Sialyl Lewis A (sLeA) |
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| Function |
Lewis antigens are series of carbohydrate epitopes with terminal fucosylation. According to different glycosidic bonds, Lewis antigens are classified as type I [H1 antigen, Lewis A (LeA), Lewis B (LeB) and Sialyl Lewis A (sLeA)] and type II [H2 antigen, Lewis X (LeX), Lewis Y (LeY) and Sialyl Lewis X (sLeX)], as shown in Figure 1. Lewis antigens are known to mediate adhesion between tumor cells and endothelium by interacting with their selectin ligands. Furthermore, upregulated expression of Lewis antigens has been reported in many types of cancers.
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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
|---|---|---|---|---|
5B1
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
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HuMAB 5B1 targeted amanitin conjugate
[1]
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Alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Undisclosed |