Antigen Information

General Information of This Antigen (ID: TAR0PPNOI)
Antigen Name
Thymidylate 5'-phosphatase (NT5E)
Gene Name
NT5E
Gene ID
4907
Synonym
NT5; NTE; 5'-deoxynucleotidase;Ecto-Thymidylate 5'-phosphatase;IMP-specific Thymidylate 5'-phosphatase;Thymidylate 5'-phosphatase;CD73
Sequence
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ

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Family
Thymidylate 5'-phosphatase family
Function
Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, with AMP being the preferred substrate. Shows a preference for ribonucleotide monophosphates over their equivalent deoxyribose forms. Other substrates include IMP, UMP, GMP, CMP, dAMP, dCMP, dTMP, NAD and NMN.

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Uniprot Entry
5NTD_HUMAN
HGNC ID
HGNC:8021
KEGG ID
hsa:4907
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
EP4494658A1 antibody-drug conjugate 1 [1]
EP4494658A1 antibody-drug conjugate 1 payload
DNA topoisomerase I (TOP1)
EP4494658A1 antibody-drug conjugate 1
 ADC Info 
EP4494658A1 antibody-drug conjugate 2 [1]
EP4494658A1 antibody-drug conjugate 1 payload
DNA topoisomerase I (TOP1)
EP4494658A1 antibody-drug conjugate 2
 ADC Info 
EP4494658A1 antibody-drug conjugate 3 [1]
EP4494658A1 antibody-drug conjugate 3 payload
Undisclosed
EP4494658A1 antibody-drug conjugate 2
 ADC Info 
EP4494658A1 antibody-drug conjugate 4 [1]
EP4494658A1 antibody-drug conjugate 3 payload
Undisclosed
EP4494658A1 antibody-drug conjugate 4
 ADC Info 
Anti-CD73 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
BB-1709
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
HB0052 [2]
SN-38
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
Anti-CD73 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD421 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Antibody-drug conjugate and use thereof
Ref 2 Huaota biopharmaceutical company product pipeline
Ref 3 Cidara therapeutics presents preclinical data on cd73-targeting drug-fc conjugate at the 2023 esmo targeted anticancer therapies congress. March 7, 2023.