Antigen Information

General Information of This Antigen
Antigen ID
TAR0PPNOI
Antigen Name
Thymidylate 5'-phosphatase (NT5E)
Gene Name
NT5E
Synonym
NT5; NTE; 5'-deoxynucleotidase;Ecto-Thymidylate 5'-phosphatase;IMP-specific Thymidylate 5'-phosphatase;Thymidylate 5'-phosphatase;CD_antigen=CD73
Sequence
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ

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Family
Thymidylate 5'-phosphatase family
Function
Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, with AMP being the preferred substrate. Shows a preference for ribonucleotide monophosphates over their equivalent deoxyribose forms. Other substrates include IMP, UMP, GMP, CMP, dAMP, dCMP, dTMP, NAD and NMN.

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Uniprot Entry
5NTD_HUMAN
HGNC ID
HGNC:8021
KEGG ID
hsa:4907
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
EP4494658A1 antibody-drug conjugate 1
EP4494658A1 antibody-drug conjugate 1 payload
DNA topoisomerase I (TOP1)
EP4494658A1 antibody-drug conjugate 1
 [1]
 ADC Info 
EP4494658A1 antibody-drug conjugate 2
EP4494658A1 antibody-drug conjugate 1 payload
DNA topoisomerase I (TOP1)
EP4494658A1 antibody-drug conjugate 2
 [1]
 ADC Info 
EP4494658A1 antibody-drug conjugate 3
EP4494658A1 antibody-drug conjugate 3 payload
Undisclosed
EP4494658A1 antibody-drug conjugate 2
 [1]
 ADC Info 
EP4494658A1 antibody-drug conjugate 4
EP4494658A1 antibody-drug conjugate 3 payload
Undisclosed
EP4494658A1 antibody-drug conjugate 4
 [1]
Anti-CD73 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
BB-1709
MMAE
Microtubule (MT)
Undisclosed
 ADC Info 
HB0052
SN-38
DNA topoisomerase 1 (TOP1)
A cleavable linker
 [2]
Anti-CD73 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CD421
Undisclosed
Undisclosed
Undisclosed
 [3]
References
Ref 1 Antibody-drug conjugate and use thereof
Ref 2 Huaota biopharmaceutical company product pipeline
Ref 3 Cidara therapeutics presents preclinical data on cd73-targeting drug-fc conjugate at the 2023 esmo targeted anticancer therapies congress. March 7, 2023.