Antigen Information

General Information of This Antigen (ID: TAR0PEUSF)
Antigen Name
Prion-like protein doppel (PRND)
Gene Name
PRND
Gene ID
23627
Synonym
DPL
Sequence
MRKHLSWWWLATVCMLLFSHLSAVQTRGIKHRIKWNRKALPSTAQITEAQVAENRPGAFI
KQGRKLDIDFGAEGNRYYEANYWQFPDGIHYNGCSEANVTKEAFVTGCINATQAANQGEF
QKPDNKLHQQVLWRLVQELCSLKHCEFWLERGAGLRVTMHQPVLLCLLALIWLTVK

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Family
Prion family
Function
FUNCTION: Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (PubMed:15218028, PubMed:20411530). {ECO:0000250|UniProtKB:Q9QUG3, ECO:0000269|PubMed:15218028, ECO:0000269|PubMed:20411530}.

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Uniprot Entry
PRND_HUMAN
HGNC ID
HGNC:15748 ,
KEGG ID
hsa:23627
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
US20240091372A1 3D5-KGDEVD-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
KGDEVD linker
 ADC Info 
US20240091372A1 3D5-vc-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
US20240091372A1 3H9-KGDEVD-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
KGDEVD linker
 ADC Info 
US20240091372A1 3H9-vc-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
US20240091372A1 3H9-DEVD-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
DEVD linker
 ADC Info 
US20240091372A1 3H9-KGDEVD-Exatecan [1]
Exatecan
DNA topoisomerase 1 (TOP1)
KGDEVD linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
US20240091372A1 4D1-KGDEVD-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
KGDEVD linker
 ADC Info 
US20240091372A1 4D1-vc-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
References
Ref 1 Anti-doppel antibody drug conjugates