Antigen Information

General Information of This Antigen
Antigen ID
TAR0OUKGL
Antigen Name
Endothelin-1 (EDN1)
Gene Name
EDN1
Synonym
EDN1
Sequence
MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMD
KECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCW
NFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSE
TMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW

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Family
Endothelin/sarafotoxin family
Function
FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (PubMed:19086031). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437). Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments (By similarity). NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). {ECO:0000250|UniProtKB:P09558, ECO:0000250|UniProtKB:P22387, ECO:0000269|PubMed:17446437, ECO:0000269|PubMed:19086031}.

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Uniprot Entry
EDN1_HUMAN
HGNC ID
HGNC:3176 ,
KEGG ID
hsa:1906 ,
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
XiRB49 MMAE
Monomethyl auristatin E
Undisclosed
Mc-Val-Cit-PABC
 [1]
References
Ref 1 Targeting the activated allosteric conformation of the endothelin receptor B in melanoma with an antibody-drug conjugate: mechanisms and therapeutic efficacy