Antigen Information

General Information of This Antigen (ID: TAR0OIMZX)
Antigen Name
CAMPATH-1 antigen (CD52)
Gene Name
CD52
Gene ID
1043
Synonym
CDW52; HE5; CDw52; Cambridge pathology 1 antigen; Epididymal secretory protein E5; Human epididymis-specific protein 5; CD52
Sequence
MKRFLFLLLTISLLVMVQIQTGLSGQNDTSQTSSPSASSNISGGIFLFFVANAIIHLFCF
S

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Function
May play a role in carrying and orienting carbohydrate, as well as having a more specific role.

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Uniprot Entry
CD52_HUMAN
HGNC ID
HGNC:1804
KEGG ID
hsa:1043
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Alemtuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Alemtuzumab-Compound 9 [1]
Mertansine DM1
Microtubule (MT)
Alemtuzumab-Compound 9 linker
 ADC Info 
Alemtuzumab-Compound 17 [1]
Mertansine DM4
Microtubule (MT)
Alemtuzumab-Compound 17 linker
 ADC Info 
Alemtuzumab-Compound 25 [1]
Monomethyl auristatin E
Microtubule (MT)
Alemtuzumab-Compound 25 linker
 ADC Info 
Alemtuzumab-Compound 31 [1]
Auristatin 0101
Microtubule (MT)
Alemtuzumab-Compound 31 linker
 ADC Info 
Alemtuzumab-Compound 36 [1]
Monomethyl auristatin E
Microtubule (MT)
Alemtuzumab-Compound 36 linker
 ADC Info 
Alemtuzumab-Compound 43 [1]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Alemtuzumab-Compound 43 linker
 ADC Info 
Alemtuzumab-Compound 49 [1]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Alemtuzumab-Compound 49 linker
 ADC Info 
Alemtuzumab-Compound 55 [1]
Mertansine DM1
Microtubule (MT)
Alemtuzumab-Compound 55 linker
 ADC Info 
Alemtuzumab-Compound 59 [1]
Mertansine DM4
Microtubule (MT)
Alemtuzumab-Compound 59 linker
 ADC Info 
Alemtuzumab-Compound 64 [1]
Monomethyl auristatin E
Microtubule (MT)
Alemtuzumab-Compound 64 linker
 ADC Info 
Alemtuzumab-Compound 69 [1]
Monomethyl auristatin E
Microtubule (MT)
Alemtuzumab-Compound 69 linker
 ADC Info 
Alemtuzumab-Compound 74 [1]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Alemtuzumab-Compound 74 linker
 ADC Info 
Alemtuzumab-Compound 75 [1]
Monomethyl auristatin E
Microtubule (MT)
Alemtuzumab-Compound 75 linker
 ADC Info 
Alemtuzumab-Compound 76 [1]
Monomethyl auristatin E
Microtubule (MT)
Alemtuzumab-Compound 76 linker
 ADC Info 
Alemtuzumab-Compound 77 [1]
Mertansine DM1
Microtubule (MT)
Alemtuzumab-Compound 77 linker
 ADC Info 
Alemtuzumab-Compound 78 [1]
Auristatin 0101
Microtubule (MT)
Alemtuzumab-Compound 78 linker
 ADC Info 
Alemtuzumab-Compound 79 [1]
Auristatin 0101
Microtubule (MT)
Alemtuzumab-Compound 79 linker
 ADC Info 
Alemtuzumab-Compound 80 [1]
Mertansine DM4
Microtubule (MT)
Alemtuzumab-Compound 80 linker
 ADC Info 
JP7623413B2 ExampleADC51 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7560255B2 ControlADC51 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-CD52 mAb 12G6 N297Q/S298N/Y300S
 Antibody Info 
ADC Name Payload Target Linker ADC Info
12G6 N297Q/S298N/Y300S-Mc-Val-Cit-PABC-MMAE [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-CD52 mAb 12G6 S298N/T299A/Y300S
 Antibody Info 
ADC Name Payload Target Linker ADC Info
12G6 S298N/T299A/Y300S-Mc-Val-Cit-PABC-MMAE [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-CD52 mAb 12G6 S298N/Y300S
 Antibody Info 
ADC Name Payload Target Linker ADC Info
12G6 S298N/Y300S-Mc-Val-Cit-PABC-MMAE [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-CD52 mAb 12G6 WT
 Antibody Info 
ADC Name Payload Target Linker ADC Info
12G6 WT-Mc-Val-Cit-PABC-MMAE [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-CD52 mAb 2C3 A114N
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2C3 A114N-Mc-Val-Cit-PABC-MMAE [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-CD52 mAb 2C3 NGT
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2C3 NGT-Mc-Val-Cit-PABC-MMAE [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-CD52 mAb 2C3 S298N Y300S
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2C3 S298N Y300S-Mc-Val-Cit-PABC-MMAE [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-CD52 mAb 2C3 S440N
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2C3 S440N-Mc-Val-Cit-PABC-MMAE [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-CD52 mAb 2C3 S442N
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2C3 S442N-Mc-Val-Cit-PABC-MMAE [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-CD52 mAb 2C3 WT
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2C3 WT-Mc-Val-Cit-PABC-MMAE [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-CD52 mAb 2C3 Y436S
 Antibody Info 
ADC Name Payload Target Linker ADC Info
2C3 Y436S-Mc-Val-Cit-PABC-MMAE [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
References
Ref 1 Covalent linkers in antibody-drug conjugates and methods of making and using the same.
Ref 2 Antibody-drug complexes containing hemiasterlin derivatives
Ref 3 Pharmaceuticals containing antibody-drug complexes containing hemiasterin derivatives
Ref 4 Site-specific antibody-drug conjugation through glycoengineering.