Antigen Information

General Information of This Antigen
Antigen ID
TAR0OHNJK
Antigen Name
Lewis Y
Function
Lewis antigens are series of carbohydrate epitopes with terminal fucosylation. According to different glycosidic bonds, Lewis antigens are classified as type I [H1 antigen, Lewis A (LeA), Lewis B (LeB) and Sialyl Lewis A (sLeA)] and type II [H2 antigen, Lewis X (LeX), Lewis Y (LeY) and Sialyl Lewis X (sLeX)], as shown in Figure 1. Lewis antigens are known to mediate adhesion between tumor cells and endothelium by interacting with their selectin ligands. Furthermore, upregulated expression of Lewis antigens has been reported in many types of cancers.

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Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-Lewis-Y mAb cBR96
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CBR96-Phe-Lys-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Phe-Lys-PABC
 [1]
 ADC Info 
cBR96-ADC-24-1
cBR96-ADC-24-1 payload
Undisclosed
cBR96-ADC-24-1 linker
 [2]
 ADC Info 
cBR96-ADC-24-2
cBR96-ADC-24-2 payload
Undisclosed
cBR96-ADC-24-2 linker
 [2]
 ADC Info 
cBR96-ADC-24-3
cBR96-ADC-24-3 payload
Undisclosed
cBR96-ADC-24-3 linker
 [2]
 ADC Info 
cBR96-ADC-24-4
cBR96-ADC-24-4 payload
Undisclosed
cBR96-ADC-24-4 linker
 [2]
 ADC Info 
cBR96-ADC-24-5
cBR96-ADC-24-5 payload
Undisclosed
cBR96-ADC-24-5 linker
 [2]
 ADC Info 
cBR96-ADC-24-6
cBR96-ADC-24-6 payload
Undisclosed
cBR96-ADC-24-6 linker
 [2]
 ADC Info 
cBR96-ADC-24-7
cBR96-ADC-24-7 payload
Undisclosed
cBR96-ADC-24-7 linker
 [2]
 ADC Info 
cBR96-ADC-24-8
cBR96-ADC-24-8 payload
Undisclosed
cBR96-ADC-24-8 linker
 [2]
 ADC Info 
cBR96-ADC-24-9
cBR96-ADC-24-9 payload
Undisclosed
cBR96-ADC-24-9 linker
 [2]
 ADC Info 
cBR96-ADC-24-10
cBR96-ADC-24-10 payload
Undisclosed
cBR96-ADC-24-10 linker
 [2]
 ADC Info 
cBR96-ADC-24-11
cBR96-ADC-24-11 payload
Undisclosed
cBR96-ADC-24-11 linker
 [2]
 ADC Info 
cBR96-ADC-24-12
cBR96-ADC-24-12 payload
Undisclosed
cBR96-ADC-24-12 linker
 [2]
 ADC Info 
cBR96-ADC-24-13
cBR96-ADC-24-13 payload
Undisclosed
cBR96-ADC-24-13 linker
 [2]
 ADC Info 
SGN-15
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
 [3]
Anti-Lewis-Y mAb G193
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CMD-193
N-acetyl-gamma-calicheamicin
Human Deoxyribonucleic acid (hDNA)
AcButDMH
 [4]
References
Ref 1 Protease-activated drug development. Theranostics. 2012;2(2):156-78.
Ref 2 Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof; 2020-04-02.
Ref 3 A randomized, multicenter study to determine the safety and efficacy of the immunoconjugate SGN-15 plus docetaxel for the treatment of non-small cell lung carcinoma. Lung Cancer. 2006 Oct;54(1):69-77. doi: 10.1016/j.lungcan.2006.05.020. Epub 2006 Aug 28.
Ref 4 Phase I biodistribution and pharmacokinetic study of Lewis Y-targeting immunoconjugate CMD-193 in patients with advanced epithelial cancers. Clin Cancer Res. 2009 Nov 1;15(21):6709-15. doi: 10.1158/1078-0432.CCR-09-0536. Epub 2009 Oct 13.

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