Antigen Information

General Information of This Antigen (ID: TAR0OHNJK)
Antigen Name
Lewis Y
Gene Name
Lewis Y
Function
Lewis antigens are series of carbohydrate epitopes with terminal fucosylation. According to different glycosidic bonds, Lewis antigens are classified as type I [H1 antigen, Lewis A (LeA), Lewis B (LeB) and Sialyl Lewis A (sLeA)] and type II [H2 antigen, Lewis X (LeX), Lewis Y (LeY) and Sialyl Lewis X (sLeX)], as shown in Figure 1. Lewis antigens are known to mediate adhesion between tumor cells and endothelium by interacting with their selectin ligands. Furthermore, upregulated expression of Lewis antigens has been reported in many types of cancers.

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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-Lewis-Y mAb cBR96
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CBR96-Phe-Lys-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Phe-Lys-PABC
 ADC Info 
CBR96-ADC-24-1 [2]
cBR96-ADC-24-1 payload
Undisclosed
cBR96-ADC-24-1 linker
 ADC Info 
CBR96-ADC-24-2 [2]
cBR96-ADC-24-2 payload
Undisclosed
cBR96-ADC-24-2 linker
 ADC Info 
CBR96-ADC-24-3 [2]
cBR96-ADC-24-3 payload
Undisclosed
cBR96-ADC-24-3 linker
 ADC Info 
CBR96-ADC-24-4 [2]
cBR96-ADC-24-4 payload
Undisclosed
cBR96-ADC-24-4 linker
 ADC Info 
CBR96-ADC-24-5 [2]
cBR96-ADC-24-5 payload
Undisclosed
cBR96-ADC-24-5 linker
 ADC Info 
CBR96-ADC-24-6 [2]
cBR96-ADC-24-6 payload
Undisclosed
cBR96-ADC-24-6 linker
 ADC Info 
CBR96-ADC-24-7 [2]
cBR96-ADC-24-7 payload
Undisclosed
cBR96-ADC-24-7 linker
 ADC Info 
CBR96-ADC-24-8 [2]
cBR96-ADC-24-8 payload
Undisclosed
cBR96-ADC-24-8 linker
 ADC Info 
CBR96-ADC-24-9 [2]
cBR96-ADC-24-9 payload
Undisclosed
cBR96-ADC-24-9 linker
 ADC Info 
CBR96-ADC-24-10 [2]
cBR96-ADC-24-10 payload
Undisclosed
cBR96-ADC-24-10 linker
 ADC Info 
CBR96-ADC-24-11 [2]
cBR96-ADC-24-11 payload
Undisclosed
cBR96-ADC-24-11 linker
 ADC Info 
CBR96-ADC-24-12 [2]
cBR96-ADC-24-12 payload
Undisclosed
cBR96-ADC-24-12 linker
 ADC Info 
CBR96-ADC-24-13 [2]
cBR96-ADC-24-13 payload
Undisclosed
cBR96-ADC-24-13 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
SGN-15
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
Acid-labile linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CMD-193
N-acetyl-gamma-calicheamicin
Human deoxyribonucleic acid (hDNA)
AcButDMH
 ADC Info 
References
Ref 1 Protease-activated drug development. Theranostics. 2012;2(2):156-78.
Ref 2 Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof; 2020-04-02.