Antigen Information

General Information of This Antigen
Antigen ID
TAR0NUXWI
Antigen Name
Cadherin-3 (CDH3)
Gene Name
CDH3
Synonym
CDHP; Placental cadherin
Sequence
MGLPRGPLASLLLLQVCWLQCAASEPCRAVFREAEVTLEAGGAEQEPGQALGKVFMGCPG
QEPALFSTDNDDFTVRNGETVQERRSLKERNPLKIFPSKRILRRHKRDWVVAPISVPENG
KGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREEIAK
YELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTAT
DEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQA
TDMDGDGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPENAVGHEVQRLTVTDLDAPNSP
AWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLKL
PTSTATIVVHVEDVNEAPVFVPPSKVVEVQEGIPTGEPVCVYTAEDPDKENQKISYRILR
DPAGWLAMDPDSGQVTAVGTLDREDEQFVRNNIYEVMVLAMDNGSPPTTGTGTLLLTLID
VNDHGPVPEPRQITICNQSPVRQVLNITDKDLSPHTSPFQAQLTDDSDIYWTAEVNEEGD
TVVLSLKKFLKQDTYDVHLSLSDHGNKEQLTVIRATVCDCHGHVETCPGPWKGGFILPVL
GAVLALLFLLLVLLLLVRKKRKIKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLHR
GLEARPEVVLRNDVAPTIIPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDTLLVF
DYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYGGGEDD

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Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

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Uniprot Entry
CADH3_HUMAN
HGNC ID
HGNC:1762
KEGG ID
hsa:1001
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-CDH3 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
BC3195
MMAE
Microtubule (MT)
Val-Cit dipeptide linker
 ADC Info 
sKB445
KL610348
DNA topoisomerase 1 (TOP1)
A cleavable linker
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
PCA062
DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
NOV169N31Q
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
NOV169N31Q-Example 1
CN119343152A 1C1-Example1 Payload
Microtubule (MT)
CN119343152A 1C1-Example1 Linker
 [1]
 ADC Info 
NOV169N31Q-Example 2
CN119343152A 1C1-Example1 Payload
Microtubule (MT)
CN119343152A 1C1-Example2 Linker
 [1]
 ADC Info 
NOV169N31Q-Example 3
CN119343152A 1C1-Example3 Payload1; CN119343152A 1C1-Example3 Payload2
Undisclosed
CN119343152A 1C1-Example3 Linker
 [1]
 ADC Info 
NOV169N31Q-Example 4
CN119343152A 1C1-Example1 Payload; CN119343152A 1C1-Example4 Payload
Undisclosed
CN119343152A 1C1-Example4 Linker
 [1]
PCAD-mab2
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
pCAD-mab2-L1-P1
L1-P1 payload
Undisclosed
L1-P1 linker
 [2]
 ADC Info 
pCAD-mab2-L2-P1
L2-P1 payload
Undisclosed
L2-P1 linker
 [2]
 ADC Info 
pCAD-mab2-L3-P1
L3-P1 payload
Undisclosed
L3-P1 linker
 [2]
 ADC Info 
pCAD-mab2-L4-P1
L4P1 payload
Microtubule (MT)
L4-P1 linker
 [2]
 ADC Info 
pCAD-mab2-L5-P1
L5-P1 payload
Undisclosed
L5-P1 linker
 [2]
 ADC Info 
pCAD-mab2-L6-P1
L4P1 payload
Microtubule (MT)
L6-P1 linker
 [2]
 ADC Info 
pCAD-mab2-L7-P2
L7-P2 payload
Undisclosed
L7-P2 linker
 [2]
W3195-1.53.1-p1-ulgG11
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
W3195-1.53.1-p1-ulgG11-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [3]
WBP319-BMK4.uIgG1k
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WBP319-BMK4.uIgG1k-DM1
Mertansine DM1
Undisclosed
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [3]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Antibody-drug conjugate (Novartis/ImmunoGen)
Undisclosed
Undisclosed
Undisclosed
 [4]
undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
igG-L1-P1
L1-P1 payload
Undisclosed
L1-P1 linker
 [2]
 ADC Info 
igG-L2-P1
L2-P1 payload
Undisclosed
L2-P1 linker
 [2]
 ADC Info 
igG-L3-P1
L3-P1 payload
Undisclosed
L3-P1 linker
 [2]
 ADC Info 
igG-L4-P1
L4P1 payload
Microtubule (MT)
L4-P1 linker
 [2]
 ADC Info 
igG-L5-P1
L5-P1 payload
Undisclosed
L5-P1 linker
 [2]
 ADC Info 
igG-L6-P1
L4P1 payload
Microtubule (MT)
L6-P1 linker
 [2]
 ADC Info 
igG-L7-P2
L7-P2 payload
Undisclosed
L7-P2 linker
 [2]
References
Ref 1 Antibody-drug conjugates
Ref 2 Antibody drug conjugates having linkers comprising hydrophilic groups
Ref 3 Antibody conjugate comprising anti-P-cadherin antibody and uses thereof
Ref 4 Introduction to basic information on antibody-drug conjugate(Novartis/ImmunoGen).