Antigen Information

General Information of This Antigen (ID: TAR0NUXWI)
Antigen Name
Cadherin-3 (CDH3)
Gene Name
CDH3
Gene ID
1001
Synonym
CDHP; Placental cadherin
Sequence
MGLPRGPLASLLLLQVCWLQCAASEPCRAVFREAEVTLEAGGAEQEPGQALGKVFMGCPG
QEPALFSTDNDDFTVRNGETVQERRSLKERNPLKIFPSKRILRRHKRDWVVAPISVPENG
KGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREEIAK
YELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTAT
DEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQA
TDMDGDGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPENAVGHEVQRLTVTDLDAPNSP
AWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLKL
PTSTATIVVHVEDVNEAPVFVPPSKVVEVQEGIPTGEPVCVYTAEDPDKENQKISYRILR
DPAGWLAMDPDSGQVTAVGTLDREDEQFVRNNIYEVMVLAMDNGSPPTTGTGTLLLTLID
VNDHGPVPEPRQITICNQSPVRQVLNITDKDLSPHTSPFQAQLTDDSDIYWTAEVNEEGD
TVVLSLKKFLKQDTYDVHLSLSDHGNKEQLTVIRATVCDCHGHVETCPGPWKGGFILPVL
GAVLALLFLLLVLLLLVRKKRKIKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLHR
GLEARPEVVLRNDVAPTIIPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDTLLVF
DYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYGGGEDD

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Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

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Uniprot Entry
CADH3_HUMAN
HGNC ID
HGNC:1762
KEGG ID
hsa:1001
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-CDH3 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
BC3195
Monomethyl auristatin E
Microtubule (MT)
Val-Cit dipeptide linker
 ADC Info 
SKB445
KL610348
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
PCA062
DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
NOV169N31Q
 Antibody Info 
ADC Name Payload Target Linker ADC Info
NOV169N31Q-Example 1 [1]
CN119343152A 1C1-Example1 Payload
Microtubule (MT)
CN119343152A 1C1-Example1 Linker
 ADC Info 
NOV169N31Q-Example 2 [1]
CN119343152A 1C1-Example1 Payload
Microtubule (MT)
CN119343152A 1C1-Example2 Linker
 ADC Info 
NOV169N31Q-Example 3 [1]
CN119343152A 1C1-Example3 Payload1; CN119343152A 1C1-Example3 Payload2
Undisclosed
CN119343152A 1C1-Example3 Linker
 ADC Info 
NOV169N31Q-Example 4 [1]
CN119343152A 1C1-Example1 Payload; CN119343152A 1C1-Example4 Payload
Undisclosed
CN119343152A 1C1-Example4 Linker
 ADC Info 
PCAD-mab2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PCAD-mab2-L1-P1 [2]
L1-P1 payload
Undisclosed
L1-P1 linker
 ADC Info 
PCAD-mab2-L2-P1 [2]
L2-P1 payload
Undisclosed
L2-P1 linker
 ADC Info 
PCAD-mab2-L3-P1 [2]
L3-P1 payload
Undisclosed
L3-P1 linker
 ADC Info 
PCAD-mab2-L4-P1 [2]
L4P1 payload
Microtubule (MT)
L4-P1 linker
 ADC Info 
PCAD-mab2-L5-P1 [2]
L5-P1 payload
Undisclosed
L5-P1 linker
 ADC Info 
PCAD-mab2-L6-P1 [2]
L4P1 payload
Microtubule (MT)
L6-P1 linker
 ADC Info 
PCAD-mab2-L7-P2 [2]
L7-P2 payload
Undisclosed
L7-P2 linker
 ADC Info 
W3195-1.53.1-p1-ulgG11
 Antibody Info 
ADC Name Payload Target Linker ADC Info
W3195-1.53.1-p1-ulgG11-MMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
WBP319-BMK4.uIgG1k
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WBP319-BMK4.uIgG1k-DM1 [3]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Antibody-drug conjugate (Novartis/ImmunoGen) [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
IgG-L1-P1 [2]
L1-P1 payload
Undisclosed
L1-P1 linker
 ADC Info 
IgG-L2-P1 [2]
L2-P1 payload
Undisclosed
L2-P1 linker
 ADC Info 
IgG-L3-P1 [2]
L3-P1 payload
Undisclosed
L3-P1 linker
 ADC Info 
IgG-L4-P1 [2]
L4P1 payload
Microtubule (MT)
L4-P1 linker
 ADC Info 
IgG-L5-P1 [2]
L5-P1 payload
Undisclosed
L5-P1 linker
 ADC Info 
IgG-L6-P1 [2]
L4P1 payload
Microtubule (MT)
L6-P1 linker
 ADC Info 
IgG-L7-P2 [2]
L7-P2 payload
Undisclosed
L7-P2 linker
 ADC Info 
References
Ref 1 Antibody-drug conjugates
Ref 2 Antibody drug conjugates having linkers comprising hydrophilic groups
Ref 3 Antibody conjugate comprising anti-P-cadherin antibody and uses thereof
Ref 4 Introduction to basic information on antibody-drug conjugate(Novartis/ImmunoGen).