Antigen Information

General Information of This Antigen
Antigen ID
TAR0LAWKO
Antigen Name
Glypican-2 (GPC2)
Gene Name
GPC2
Gene ID
221914
Sequence
MSALRPLLLLLLPLCPGPGPGPGSEAKVTRSCAETRQVLGARGYSLNLIPPALISGEHLR
VCPQEYTCCSSETEQRLIRETEATFRGLVEDSGSFLVHTLAARHRKFDEFFLEMLSVAQH
SLTQLFSHSYGRLYAQHALIFNGLFSRLRDFYGESGEGLDDTLADFWAQLLERVFPLLHP
QYSFPPDYLLCLSRLASSTDGSLQPFGDSPRRLRLQITRTLVAARAFVQGLETGRNVVSE
ALKVPVSEGCSQALMRLIGCPLCRGVPSLMPCQGFCLNVVRGCLSSRGLEPDWGNYLDGL
LILADKLQGPFSFELTAESIGVKISEGLMYLQENSAKVSAQVFQECGPPDPVPARNRRAP
PPREEAGRLWSMVTEEERPTTAAGTNLHRLVWELRERLARMRGFWARLSLTVCGDSRMAA
DASLEAAPCWTGAGRGRYLPPVVGGSPAEQVNNPELKVDASGPDVPTRRRRLQLRAA.MK
TAALGHDLDGQDADEDASGSGGGQQYADDWMAGAVAPPARPPRPPYPPRRDGSGGKGGGG
SARYNQGRSRSGGASIGFHTQTILILSLSALALLGPR

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Family
Glypican family
Function
Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons.

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Uniprot Entry
GPC2_HUMAN
HGNC ID
HGNC:4450
KEGG ID
hsa:221914
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Fully human D3-GPC2-IgG1
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
D3-GPC2-PBD
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 [1]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-GPC2 ADC
Undisclosed
Undisclosed
Undisclosed
 [2]
References
Ref 1 A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope. Cell Rep Med. 2021 Jul 21;2(7):100344.
Ref 2 GPC2 antibody-drug conjugate reprograms the neuroblastoma immune milieu to enhance macrophage-driven therapies. J Immunother Cancer. 2022 Dec;10(12):e004704. doi: 10.1136/jitc-2022-004704.

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