Antigen Information

General Information of This Antigen (ID: TAR0KKFFR)
Antigen Name
Interleukin-1 receptor-like 1 (IL1RL1)
Gene Name
IL1RL1
Gene ID
9173
Synonym
DER4; ST2; T1; Protein ST2
Sequence
MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQ
ERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYS
TVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYT
CKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFG
KGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQ
YDCLALNLHGLRRHTVRLSRKNPIDHHSIYCIIAVCSVFLMLINVLVIILKMFWIEATLL
WRDIAKPYKTRNDGKLYDAYVVYPRNYKSSTDGASRVEHFVHQILPDVLENKCGYTLCIY
GRDMLPGEDVVTAVETNIRKSRRHIFILTPQITHNKEFAYEQEVALHCALIQNDAKVILI
EMEALSELDMLQAEALQDSLQHLMKVQGTIKWREDHIANKRSLNSKFWKHVRYQMPVPSK
IPRKASSLTPLAAQKQ

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Family
Interleukin-1 receptor family
Function
Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T- cell function (Probable). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3- dependent differentiation of inflammation-resolving alternatively activated macrophages.

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Uniprot Entry
ILRL1_HUMAN
HGNC ID
HGNC:5998
KEGG ID
hsa:9173
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-IL1RL1 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
T1LD7 [1]
N-acetyl-gamma-calicheamicin
Human Deoxyribonucleic acid (hDNA)
Mal-Val-Cit-PABC-EDA
 ADC Info 
T1LD6 [1]
N-methyl-uncialamycin
Human Deoxyribonucleic acid (hDNA)
Mal-Val-Cit-gucuronide-PEG8-PABC
 ADC Info 
T1LD5 [1]
N-methyl-uncialamycin
Human Deoxyribonucleic acid (hDNA)
Mal-Val-Cit-glucuronide-PABC
 ADC Info 
T1LD4 [1]
N-methyl-uncialamycin
Human Deoxyribonucleic acid (hDNA)
Mal-glucuronidase cleavable linker
 ADC Info 
T1LD3 [1]
N-methyl-uncialamycin
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8
 ADC Info 
T1LD2 [1]
N-methyl-uncialamycin
Human Deoxyribonucleic acid (hDNA)
Mal-acetic acid
 ADC Info 
T1LD1 [1]
N-methyl-uncialamycin
Human Deoxyribonucleic acid (hDNA)
Mal-Val-Cit-PABC
 ADC Info 
References
Ref 1 Uncialamycin-based antibody-drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2107042118. doi: 10.1073/pnas.2107042118.