Antigen Information

General Information of This Antigen
Antigen ID
TAR0KFMNY
Antigen Name
C-type lectin domain family 4 member C (CLEC4C)
Gene Name
CLEC4C
Gene ID
170482
Synonym
BDCA2; CLECSF11; CLECSF7; DLEC; HECL; Blood dendritic cell antigen 2;C-type lectin superfamily member 7;Dendritic lectin;CD_antigen=CD303
Sequence
MVPEEEPQDREKGLWWFQLKVWSMAVVSILLLSVCFTVSSVVPHNFMYSKTVKRLSKLRE
YQQYHPSLTCVMEGKDIEDWSCCPTPWTSFQSSCYFISTGMQSWTKSQKNCSVMGADLVV
INTREEQDFIIQNLKRNSSYFLGLSDPGGRRHWQWVDQTPYNENVTFWHSGEPNNLDERC
AIINFRSSEEWGWNDIHCHVPQKSICKMKKIYI

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Function
Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells. Specifically recognizes non-sialylated galactose- terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. Binds to serum IgG. Efficiently .gets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium.

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Uniprot Entry
CLC4C_HUMAN
HGNC ID
HGNC:13258
KEGG ID
hsa:170482
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
DB-2304
P2025 glucocorticoid receptor agonist
Glucocorticoid receptor (NR3C1)
Undisclosed
 [1]
References
Ref 1 DB-2304, a Novel anti-BDCA2 Monoclonal Antibody Drug Conjugate, Displayed Great Potency in Suppression of pDC Functions. Arthritis Rheumatol. 2022; 74 (suppl 9).