Antigen Information

General Information of This Antigen
Antigen ID
TAR0KFMNY
Antigen Name
C-type lectin domain family 4 member C (CLEC4C)
Gene Name
CLEC4C
Gene ID
170482
Synonym
BDCA2; CLECSF11; CLECSF7; DLEC; HECL; Blood dendritic cell antigen 2;C-type lectin superfamily member 7;Dendritic lectin;CD_antigen=CD303
Sequence
MVPEEEPQDREKGLWWFQLKVWSMAVVSILLLSVCFTVSSVVPHNFMYSKTVKRLSKLRE
YQQYHPSLTCVMEGKDIEDWSCCPTPWTSFQSSCYFISTGMQSWTKSQKNCSVMGADLVV
INTREEQDFIIQNLKRNSSYFLGLSDPGGRRHWQWVDQTPYNENVTFWHSGEPNNLDERC
AIINFRSSEEWGWNDIHCHVPQKSICKMKKIYI

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Function
Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells. Specifically recognizes non-sialylated galactose- terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. Binds to serum IgG. Efficiently .gets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium.

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Uniprot Entry
CLC4C_HUMAN
HGNC ID
HGNC:13258
KEGG ID
hsa:170482
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
CLEC4C BIIB059
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
BDCA2-ADC
DIMAC Payload
Undisclosed
a cleavable linker containing maleimide tetrapeptide
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
DB-2304
P2025
Glucocorticoid receptor (NR3C1)
A cleavable linker
References
Ref 1 An immunomodulatory antibody-drug conjugate targeting BDCA2 strongly suppresses plasmacytoid dendritic cell function and glucocorticoid responsive genes