Antigen Information
General Information of This Antigen (ID: TAR0KFMNY)
| Antigen Name | C-type lectin domain family 4 member C (CLEC4C) |
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| Gene Name | CLEC4C |
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| Synonym | BDCA2; CLECSF11; CLECSF7; DLEC; HECL; Blood dendritic cell antigen 2;C-type lectin superfamily member 7;Dendritic lectin;CD303 |
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| Sequence |
MVPEEEPQDREKGLWWFQLKVWSMAVVSILLLSVCFTVSSVVPHNFMYSKTVKRLSKLRE
YQQYHPSLTCVMEGKDIEDWSCCPTPWTSFQSSCYFISTGMQSWTKSQKNCSVMGADLVV INTREEQDFIIQNLKRNSSYFLGLSDPGGRRHWQWVDQTPYNENVTFWHSGEPNNLDERC AIINFRSSEEWGWNDIHCHVPQKSICKMKKIYI Click to Show/Hide
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| Function |
Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells. Specifically recognizes non-sialylated galactose- terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. Binds to serum IgG. Efficiently .gets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium.
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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
|---|---|---|---|---|
CLEC4C BIIB059
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
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BDCA2-ADC
[1]
|
DIMAC Payload |
Undisclosed |
a cleavable linker containing maleimide tetrapeptide |
Hu033-03
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
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DB-2304
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P2025 |
Glucocorticoid receptor (NR3C1) |
A cleavable linker |
References