Antigen Information

General Information of This Antigen
Antigen ID
TAR0HYSKU
Antigen Name
T-cell antigen CD7 (CD7)
Gene Name
CD7
Synonym
GP40;T-cell leukemia antigen;T-cell surface antigen Leu-9;TP41;CD_antigen=CD7
Sequence
MAGPPRLLLLPLLLALARGLPGALAAQEVQQSPHCTTVPVGASVNITCSTSGGLRGIYLR
QLGPQPQDIIYYEDGVVPTTDRRFRGRIDFSGSQDNLTITMHRLQLSDTGTYTCQAITEV
NVYGSGTLVLVTEEQSQGWHRCSDAPPRASALPAPPTGSALPDPQTASALPDPPAASALP
AALAVISFLLGLGLGVACVLARTQIKKLCSWRDKNSAACVVYEDMSHSRCNTLSSPNQYQ

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Function
Not yet known.

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Uniprot Entry
CD7_HUMAN
HGNC ID
HGNC:1695
KEGG ID
hsa:924
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-CD7 mAb HB2
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Monoclonal antibody HB2-saporin conjugate
Saporin
Microtubule (MT)
Undisclosed
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
DhuVHH6-PE-LR
Pseudomonas exotoxin PE38 with protease-resistant (PE-LR)
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 [2]
Grisnilimab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Grisnilimab setaritox
Topoisomerase inhibitor
Undisclosed
Undisclosed
 [3]
Human Anti-CD7 mAb IgG1
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-CD7 MMAE ADC
Monomethyl auristatin E
Microtubule (MT)
PermaLink-PEG4-Val-Cit-PAB
 [4]
Humanized CD7 nanobody Dvhh6
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
DVHH6-PE38
Pseudomonas exotoxin PE38
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 [2]
 ADC Info 
DVHH6-PE-LR
Pseudomonas exotoxin PE38 with protease-resistant (PE-LR)
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 [2]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
J87-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 [5]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
DhuVHH6-PE38
Undisclosed
Undisclosed
Undisclosed
 [2]
References
Ref 1 Effectiveness of HB2 (anti-CD7)--saporin immunotoxin in an in vivo model of human T-cell leukaemia developed in severe combined immunodeficient mice. Br J Cancer. 1994 Feb;69(2):279-85. doi: 10.1038/bjc.1994.52.
Ref 2 Humanized CD7 nanobody-based immunotoxins exhibit promising anti-T-cell acute lymphoblastic leukemia potential. Int J Nanomedicine. 2017 Mar 13;12:1969-1983. doi: 10.2147/IJN.S127575. eCollection 2017.
Ref 3 ADC review: basic information about Grisnilimab setaritox.
Ref 4 An antibody-drug conjugate with intracellular drug release properties showing specific cytotoxicity against CD7-positive cells. Leuk Res. 2021 Sep;108:106626. doi: 10.1016/j.leukres.2021.106626.
Ref 5 An Anti-CD7 Antibody-Drug Conjugate Target Showing Potent Antitumor Activity for T-Lymphoblastic Leukemia (T-ALL)