Antigen Information

General Information of This Antigen (ID: TAR0HYSKU)
Antigen Name
T-cell antigen CD7 (CD7)
Gene Name
CD7
Gene ID
924
Synonym
GP40;T-cell leukemia antigen;T-cell surface antigen Leu-9;TP41;CD7
Sequence
MAGPPRLLLLPLLLALARGLPGALAAQEVQQSPHCTTVPVGASVNITCSTSGGLRGIYLR
QLGPQPQDIIYYEDGVVPTTDRRFRGRIDFSGSQDNLTITMHRLQLSDTGTYTCQAITEV
NVYGSGTLVLVTEEQSQGWHRCSDAPPRASALPAPPTGSALPDPQTASALPDPPAASALP
AALAVISFLLGLGLGVACVLARTQIKKLCSWRDKNSAACVVYEDMSHSRCNTLSSPNQYQ

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Function
Not yet known.

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Uniprot Entry
CD7_HUMAN
HGNC ID
HGNC:1695
KEGG ID
hsa:924
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-CD7 mAb HB2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Monoclonal antibody HB2-saporin conjugate [1]
Saporin
Microtubule (MT)
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
DhuVHH6-PE-LR [2]
Pseudomonas exotoxin PE38 with protease-resistant (PE-LR)
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 ADC Info 
Grisnilimab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Grisnilimab setaritox [3]
Topoisomerase inhibitor
Undisclosed
Undisclosed
 ADC Info 
Human Anti-CD7 mAb IgG1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-CD7 MMAE ADC [4]
Monomethyl auristatin E
Microtubule (MT)
PermaLink-PEG4-Val-Cit-PAB
 ADC Info 
Humanized CD7 nanobody Dvhh6
 Antibody Info 
ADC Name Payload Target Linker ADC Info
DVHH6-PE38 [2]
Pseudomonas exotoxin PE38
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 ADC Info 
DVHH6-PE-LR [2]
Pseudomonas exotoxin PE38 with protease-resistant (PE-LR)
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
J87-Dxd [5]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
DhuVHH6-PE38 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Effectiveness of HB2 (anti-CD7)--saporin immunotoxin in an in vivo model of human T-cell leukaemia developed in severe combined immunodeficient mice. Br J Cancer. 1994 Feb;69(2):279-85. doi: 10.1038/bjc.1994.52.
Ref 2 Humanized CD7 nanobody-based immunotoxins exhibit promising anti-T-cell acute lymphoblastic leukemia potential. Int J Nanomedicine. 2017 Mar 13;12:1969-1983. doi: 10.2147/IJN.S127575. eCollection 2017.
Ref 3 ADC review: basic information about Grisnilimab setaritox.
Ref 4 An antibody-drug conjugate with intracellular drug release properties showing specific cytotoxicity against CD7-positive cells. Leuk Res. 2021 Sep;108:106626. doi: 10.1016/j.leukres.2021.106626.
Ref 5 An Anti-CD7 Antibody-Drug Conjugate Target Showing Potent Antitumor Activity for T-Lymphoblastic Leukemia (T-ALL)