Antigen Information
General Information of This Antigen (ID: TAR0HOZZG)
| Antigen Name | Epiregulin (EREG) |
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| Gene Name | EREG |
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| Gene ID | ||||||
| Synonym | EREG |
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| Sequence |
MTAGRRMEMLCAGRVPALLLCLGFHLLQAVLSTTVIPSCIPGESSDNCTALVQTEDNPRV
AQVSITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFLTVHQPLSKEYVA LTVILIILFLITVVGSTYYFCRWYRNRKSKEPKKEYERVTSGDPELPQV Click to Show/Hide
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| Function |
FUNCTION: Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357). {ECO:0000269|PubMed:9419975, ECO:0000303|PubMed:24631357}.
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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
|---|---|---|---|---|
H231
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
H231 VC-cDuoDM
[1]
|
Undisclosed |
Undisclosed |
DBCO-PEG4-VC-PABC-PEG2 |
|
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H232 EGC-cDuoDM
[1]
|
Undisclosed |
Undisclosed |
BCN-PEG3-EGC-PABC-SPACER |
|
|
H233 VC-qDuoDM gluc
[1]
|
Undisclosed |
Undisclosed |
BCN-PEG3-EGC-PABQ |
|
|
VC-PABC-DuoDM ADC
[2]
|
Duocarmycin DM |
Undisclosed |
DBCO-PEG4-VC-PABC- (PEG2) |
|
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EGC-PABC-DuoDM ADC
[2]
|
Duocarmycin DM |
Undisclosed |
BCN-PEG3-EGC-PABC |
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EGC-PABQ-DuoDM gluc ADC
[2]
|
Duocarmycin DM |
Undisclosed |
DBCO-PEG3-EGC-PABQ |
References