Antigen Information
General Information of This Antigen (ID: TAR0GFSKS)
| Antigen Name | Ephrin type-A receptor 2 (EPHA2) |
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|---|---|---|---|---|---|---|
| Gene Name | EPHA2 |
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| Gene ID | ||||||
| Synonym | ECK; Epithelial cell kinase;Tyrosine-protein kinase receptor ECK |
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| Sequence |
MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMN
DMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFN LYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYL AFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGG EEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPS PEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDI VYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSG LVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSN SYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGG VAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQA VLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDF LGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGML RGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIP IRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPM DCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSG SEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAY SLLGLKDQVNTVGIPI Click to Show/Hide
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| Family | Tyr protein family |
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| Function |
Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin- A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand- independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
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| Uniprot Entry | ||||||
| HGNC ID | ||||||
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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
|---|---|---|---|---|
1C1
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
CN119343152A 1C1-Example 1
[1]
|
CN119343152A 1C1-Example1 Payload |
Microtubule (MT) |
CN119343152A 1C1-Example1 Linker |
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CN119343152A 1C1-Example 2
[1]
|
CN119343152A 1C1-Example1 Payload |
Microtubule (MT) |
CN119343152A 1C1-Example2 Linker |
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CN119343152A 1C1-Example 3
[1]
|
CN119343152A 1C1-Example3 Payload1; CN119343152A 1C1-Example3 Payload2 |
Undisclosed |
CN119343152A 1C1-Example3 Linker |
|
|
CN119343152A 1C1-Example 4
[1]
|
CN119343152A 1C1-Example1 Payload; CN119343152A 1C1-Example4 Payload |
Undisclosed |
CN119343152A 1C1-Example4 Linker |
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AB206-ADL1-D1
[2]
|
D1 payload |
Undisclosed |
Mc-Val-Cit-PABC |
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AB206-ADL5-D2
[2]
|
D2 payload |
Undisclosed |
Mc-Val-Cit-PAB (Qamine) linker |
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|
AB206-ADL1-D4
[2]
|
D4 payload |
Undisclosed |
Mc-Val-Cit-PABC |
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|
AB206-ADL1-D8
[2]
|
D8 payload |
Undisclosed |
Mc-Val-Cit-PABC |
|
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AB206-ADL1-D14
[2]
|
D14 payload |
Undisclosed |
Mc-Val-Cit-PABC |
|
|
AB206-ADL5-D19
[2]
|
D19 payload |
Undisclosed |
Mc-Val-Cit-PAB (Qamine) linker |
|
|
AB206-ADL5-D25
[2]
|
D25 payload |
Undisclosed |
Mc-Val-Cit-PABC |
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AB206-ADL10-D1
[2]
|
D1 payload |
Undisclosed |
6-Maleimidocaproic acid |
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AB206-ADL12-D1
[2]
|
D1 payload |
Undisclosed |
Mal- (CH2)6- linker |
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AB206-ADL12-D2
[2]
|
D2 payload |
Undisclosed |
Mal- (CH2)6- linker |
Anti-EPHA2 (1C1) mAb
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
MEDI-547
|
Monomethyl auristatin F |
Microtubule (MT) |
Maleimido-caproyl |
Anti-EPHA2 mAb
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
EphA2-targeted mAb ADC 11
[3]
|
EphA2-targeted mAb ADC 11 payload |
Undisclosed |
EphA2-targeted mAb ADC 11 linker |
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EphA2-targeted mAb ADC 17
[3]
|
EphA2-targeted mAb ADC 17 payload |
Undisclosed |
EphA2-targeted mAb ADC 17 linker |
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EphA2-targeted mAb ADC 19
[3]
|
EphA2-targeted mAb ADC 19 payload |
Undisclosed |
EphA2-targeted mAb ADC 19 linker |
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EphA2-targeted mAb ADC 20
[3]
|
EphA2-targeted mAb ADC 20 payload |
Undisclosed |
EphA2-targeted mAb ADC 20 linker |
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EphA2-targeted mAb ADC 21
[3]
|
EphA2-targeted mAb ADC 21 payload |
Undisclosed |
EphA2-targeted mAb ADC 21 linker |
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EphA2-targeted mAb ADC 22
[3]
|
EphA2-targeted mAb ADC 22 payload |
Undisclosed |
EphA2-targeted mAb ADC 22 linker |
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EphA2-targeted mAb ADC 23
[3]
|
EphA2-targeted mAb ADC 23 payload |
Undisclosed |
EphA2-targeted mAb ADC 23 linker |
|
|
EphA2-targeted mAb ADC 24
[3]
|
EphA2-targeted mAb ADC 24 payload |
Undisclosed |
EphA2-targeted mAb ADC 24 linker |
|
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EphA2-targeted mAb ADC 25
[3]
|
EphA2-targeted mAb ADC 25 payload |
Undisclosed |
EphA2-targeted mAb ADC 25 linker |
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EphA2-targeted mAb ADC 26
[3]
|
EphA2-targeted mAb ADC 26 payload |
Undisclosed |
EphA2-targeted mAb ADC 26 linker |
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EphA2-targeted mAb ADC 27
[3]
|
EphA2-targeted mAb ADC 27 payload |
Undisclosed |
EphA2-targeted mAb ADC 27 linker |
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EphA2-targeted mAb ADC 66
[3]
|
EphA2-targeted mAb ADC 66 payload |
Undisclosed |
EphA2-targeted mAb ADC 66 linker |
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EphA2-targeted mAb ADC 67
[3]
|
EphA2-targeted mAb ADC 67 payload |
Undisclosed |
EphA2-targeted mAb ADC 67 linker |
|
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EphA2-targeted mAb ADC 68
[3]
|
EphA2-targeted mAb ADC 68 payload |
Undisclosed |
EphA2-targeted mAb ADC 68 linker |
|
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EphA2-targeted mAb ADC 69
[3]
|
EphA2-targeted mAb ADC 69 payload |
Undisclosed |
EphA2-targeted mAb ADC 69 linker |
|
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EphA2-targeted mAb ADC 96
[3]
|
EphA2-targeted mAb ADC 96 payload |
Undisclosed |
EphA2-targeted mAb ADC 96 linker |
|
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EphA2-targeted mAb ADC 98
[3]
|
EphA2-targeted mAb ADC 98 payload |
Undisclosed |
EphA2-targeted mAb ADC 98 linker |
|
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EphA2-targeted mAb ADC 101
[3]
|
EphA2-targeted mAb ADC 101 payload |
Undisclosed |
EphA2-targeted mAb ADC 101 linker |
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EphA2-targeted mAb ADC 102
[3]
|
EphA2-targeted mAb ADC 102 payload |
Undisclosed |
EphA2-targeted mAb ADC 102 linker |
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EphA2-targeted mAb ADC 103
[3]
|
EphA2-targeted mAb ADC 103 payload |
Undisclosed |
EphA2-targeted mAb ADC 103 linker |
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EphA2-targeted mAb ADC 104
[3]
|
EphA2-targeted mAb ADC 104 payload |
Undisclosed |
EphA2-targeted mAb ADC 104 linker |
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EphA2-targeted mAb ADC 105
[3]
|
EphA2-targeted mAb ADC 105 payload |
Undisclosed |
EphA2-targeted mAb ADC 105 linker |
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EphA2-targeted mAb ADC 106
[3]
|
EphA2-targeted mAb ADC 106 payload |
Undisclosed |
EphA2-targeted mAb ADC 106 linker |
|
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EphA2-targeted mAb ADC 107
[3]
|
EphA2-targeted mAb ADC 107 payload |
Undisclosed |
EphA2-targeted mAb ADC 107 linker |
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EphA2-targeted mAb ADC 108
[3]
|
EphA2-targeted mAb ADC 108 payload |
Undisclosed |
EphA2-targeted mAb ADC 108 linker |
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EphA2-targeted mAb ADC 109
[3]
|
EphA2-targeted mAb ADC 109 payload |
Undisclosed |
EphA2-targeted mAb ADC 109 linker |
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EphA2-targeted mAb ADC 110
[3]
|
EphA2-targeted mAb ADC 110 payload |
Undisclosed |
EphA2-targeted mAb ADC 110 linker |
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EphA2-targeted mAb ADC 111
[3]
|
EphA2-targeted mAb ADC 111 payload |
Undisclosed |
EphA2-targeted mAb ADC 111 linker |
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EphA2-targeted mAb ADC 112
[3]
|
EphA2-targeted mAb ADC 112 payload |
Undisclosed |
EphA2-targeted mAb ADC 112 linker |
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EphA2-targeted mAb ADC 121
[3]
|
EphA2-targeted mAb ADC 121 payload |
Undisclosed |
EphA2-targeted mAb ADC 121 linker |
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EphA2-targeted mAb ADC 122
[3]
|
EphA2-targeted mAb ADC 122 payload |
Undisclosed |
EphA2-targeted mAb ADC 122 linker |
|
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EphA2-targeted mAb ADC 123
[3]
|
EphA2-targeted mAb ADC 123 payload |
Undisclosed |
EphA2-targeted mAb ADC 123 linker |
|
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EphA2-targeted mAb ADC 124
[3]
|
EphA2-targeted mAb ADC 124 payload |
Undisclosed |
EphA2-targeted mAb ADC 124 linker |
|
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EphA2-targeted mAb ADC 125
[3]
|
EphA2-targeted mAb ADC 125 payload |
Undisclosed |
EphA2-targeted mAb ADC 125 linker |
|
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EphA2-targeted mAb ADC 126
[3]
|
EphA2-targeted mAb ADC 126 payload |
Undisclosed |
EphA2-targeted mAb ADC 126 linker |
|
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EphA2-targeted mAb ADC 128
[3]
|
EphA2-targeted mAb ADC 128 payload |
Undisclosed |
EphA2-targeted mAb ADC 128 linker |
|
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EphA2-targeted mAb ADC 131
[3]
|
EphA2-targeted mAb ADC 131 payload |
Undisclosed |
EphA2-targeted mAb ADC 131 linker |
|
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EphA2-targeted mAb ADC 133
[3]
|
EphA2-targeted mAb ADC 133 payload |
Undisclosed |
EphA2-targeted mAb ADC 133 linker |
|
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EphA2-targeted mAb ADC 134
[3]
|
EphA2-targeted mAb ADC 134 payload |
Undisclosed |
EphA2-targeted mAb ADC 134 linker |
|
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EphA2-targeted mAb ADC 144
[3]
|
EphA2-targeted mAb ADC 144 payload |
Undisclosed |
EphA2-targeted mAb ADC 144 linker |
|
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EphA2-targeted mAb ADC 145
[3]
|
EphA2-targeted mAb ADC 145 payload |
Undisclosed |
EphA2-targeted mAb ADC 145 linker |
|
|
EphA2-targeted mAb ADC 146
[3]
|
EphA2-targeted mAb ADC 146 payload |
Undisclosed |
EphA2-targeted mAb ADC 146 linker |
|
|
EphA2-targeted mAb ADC 147
[3]
|
EphA2-targeted mAb ADC 147 payload |
Undisclosed |
EphA2-targeted mAb ADC 147 linker |
|
|
EphA2-targeted mAb ADC 148
[3]
|
EphA2-targeted mAb ADC 148 payload |
Undisclosed |
EphA2-targeted mAb ADC 148 linker |
|
|
EphA2-targeted mAb ADC 149
[3]
|
EphA2-targeted mAb ADC 149 payload |
Undisclosed |
EphA2-targeted mAb ADC 149 linker |
|
|
EphA2-targeted mAb ADC 150
[3]
|
EphA2-targeted mAb ADC 150 payload |
Undisclosed |
EphA2-targeted mAb ADC 150 linker |
|
|
EphA2-targeted mAb ADC 151
[3]
|
EphA2-targeted mAb ADC 151 payload |
Undisclosed |
EphA2-targeted mAb ADC 151 linker |
|
|
EphA2-targeted mAb ADC 152
[3]
|
EphA2-targeted mAb ADC 152 payload |
Undisclosed |
EphA2-targeted mAb ADC 152 linker |
|
|
EphA2-targeted mAb ADC A 12 (DAR8)
[3]
|
EphA2-targeted mAb ADC A 12 (DAR8) payload |
Undisclosed |
EphA2-targeted mAb ADC A 12 (DAR8) linker |
|
|
EphA2-targeted mAb ADC A 12 (DAR4)
[3]
|
EphA2-targeted mAb ADC A 12 (DAR4) payload |
Undisclosed |
EphA2-targeted mAb ADC A 12 (DAR4) linker |
|
|
EphA2-targeted mAb ADC A 17 (DAR8)
[3]
|
EphA2-targeted mAb ADC A 17 (DAR8) payload |
Undisclosed |
EphA2-targeted mAb ADC A 17 (DAR8) linker |
|
|
EphA2-targeted mAb ADC A 17 (DAR4)
[3]
|
EphA2-targeted mAb ADC A 17 (DAR4) payload |
Undisclosed |
EphA2-targeted mAb ADC A 17 (DAR4) linker |
|
|
EphA2-targeted mAb ADC A 21 (DAR8)
[3]
|
EphA2-targeted mAb ADC A 21 (DAR8) payload |
Undisclosed |
EphA2-targeted mAb ADC A 21 (DAR8) linker |
|
|
EphA2-targeted mAb ADC A 21 (DAR4)
[3]
|
EphA2-targeted mAb ADC A 21 (DAR4) payload |
Undisclosed |
EphA2-targeted mAb ADC A 21 (DAR4) linker |
|
|
EphA2-targeted mAb ADC A 22 (DAR6)
[3]
|
EphA2-targeted mAb ADC A 22 (DAR6) payload |
Undisclosed |
EphA2-targeted mAb ADC A 22 (DAR6) linker |
|
|
EphA2-targeted mAb ADC A 22 (DAR2)
[3]
|
EphA2-targeted mAb ADC A 22 (DAR2) payload |
Undisclosed |
EphA2-targeted mAb ADC A 22 (DAR2) linker |
|
|
EphA2-targeted mAb ADC A 19 (DAR8)
[3]
|
EphA2-targeted mAb ADC A 19 (DAR8) payload |
Undisclosed |
EphA2-targeted mAb ADC A 19 (DAR8) linker |
|
|
EphA2-targeted mAb ADC A 19 (DAR4)
[3]
|
EphA2-targeted mAb ADC A 19 (DAR4) payload |
Undisclosed |
EphA2-targeted mAb ADC A 19 (DAR4) linker |
|
|
EphA2-targeted mAb ADC A 20 (DAR8)
[3]
|
EphA2-targeted mAb ADC A 20 (DAR8) payload |
Undisclosed |
EphA2-targeted mAb ADC A 20 (DAR8) linker |
|
|
EphA2-targeted mAb ADC A 20 (DAR4)
[3]
|
EphA2-targeted mAb ADC A 20 (DAR4) payload |
Undisclosed |
EphA2-targeted mAb ADC A 20 (DAR4) linker |
|
|
EphA2-targeted mAb ADC A 24 (DAR8)
[3]
|
EphA2-targeted mAb ADC A 24 (DAR8) payload |
Undisclosed |
EphA2-targeted mAb ADC A 24 (DAR8) linker |
|
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EphA2-targeted mAb ADC A 24 (DAR4)
[3]
|
EphA2-targeted mAb ADC A 24 (DAR4) payload |
Undisclosed |
EphA2-targeted mAb ADC A 24 (DAR4) linker |
|
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EphA2-targeted mAb ADC A 23 (DAR8)
[3]
|
EphA2-targeted mAb ADC A 23 (DAR8) payload |
Undisclosed |
EphA2-targeted mAb ADC A 23 (DAR8) linker |
|
|
EphA2-targeted mAb ADC A 23 (DAR4)
[3]
|
EphA2-targeted mAb ADC A 23 (DAR4) payload |
Undisclosed |
EphA2-targeted mAb ADC A 23 (DAR4) linker |
Anti-EPHA2 mAb 1C1
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
1C1-mcMMAF
[4]
|
Monomethyl auristatin F |
Microtubule (MT) |
Maleimido-caproyl |
|
|
CN106459205B ADC-1
[5]
|
CN106459205B ADC-1 payload |
Undisclosed |
CN106459205B ADC-1 linker |
|
|
CN106459205B ADC-2
[5]
|
CN106459205B ADC-2 payload |
Undisclosed |
CN106459205B ADC-2 linker |
|
|
CN106459205B ADC-3
[5]
|
CN106459205B ADC-3 payload |
Undisclosed |
CN106459205B ADC-3 linker |
|
|
CN106459205B ADC-4
[5]
|
CN106459205B ADC-4 payload |
Undisclosed |
CN106459205B ADC-4 linker |
|
|
CN106459205B ADC-5
[5]
|
CN106459205B ADC-5 payload |
Undisclosed |
CN106459205B ADC-5 linker |
EphA2-1C1
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
EphA2-1C1-L101-D101
[6]
|
Compound D101 |
Undisclosed |
L101 linker |
|
|
EphA2-1C1-L102-D101
[6]
|
Compound D101 |
Undisclosed |
L102 linker |
|
|
EphA2-1C1-L103-D101
[6]
|
Compound D101 |
Undisclosed |
L103 linker |
|
|
EphA2-1C1-L101-D102
[6]
|
Compound D102 |
Undisclosed |
L101 linker |
|
|
EphA2-1C1-L101-D103
[6]
|
Compound D103 |
Undisclosed |
L101 linker |
|
|
EphA2-1C1-L101-D104
[6]
|
Compound D104 |
Undisclosed |
L101 linker |
|
|
EphA2-1C1-L102-D102
[6]
|
Compound D102 |
Undisclosed |
L102 linker |
|
|
EphA2-1C1-L102-D103
[6]
|
Compound D103 |
Undisclosed |
L102 linker |
|
|
EphA2-1C1-L102-D104
[6]
|
Compound D104 |
Undisclosed |
L102 linker |
Undisclosed
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
MM-310
|
Docetaxel |
Undisclosed |
Undisclosed |
|
|
SAB-Y9-59
[7]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SAB-Y20
[8]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SAB-Y19
[9]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ATRC-301
[10]
|
Undisclosed |
Undisclosed |
Undisclosed |
References