Antigen Information

General Information of This Antigen

Antigen ID	TAR0GDENB
Antigen Name	Tumor-associated glycoprotein 72 (TAG-72)
Function	Tumor-associated glycoprotein 72 (TAG72) is a cell surface glycoprotein that functions similar to an MUC and is often overexpressed in and shed from pancreas cancer (PC). It is known to be a better prognostic indicator than CA19.9 or CEA. Despite this and the fact that Indium-111 satumomab pendetide, a derivative of the anti-TAG72 antibody B72.3, was the first monoclonal antibody to be approved for tumor imaging, other attempted applications of anti-TAG72 mAbs fizzled out. Click to Show/Hide

Each Antibody-drug Conjuate AND It's Component Related to This Antigen

Full List of The ADC Related to This Antigen

Anti-TAG-72 antibody

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TGW101	MMAE	Microtubule (MT)	A cleavable linker	[1]

Anti-TAG-72 mAb

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TGW-101	Undisclosed	Undisclosed	Undisclosed	[2]

AVP04

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	ADC-AVP-04	Monomethyl auristatin E	Microtubule (MT)	Maleimide-functionalized TCO	[3]

undisclosed

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	anti-TAG-72 ADC	Monomethyl auristatin E	Undisclosed	Undisclosed	[4]

References

Ref 1	Preclinical development of TGW101, a first in class click-cleavable ADC with MMAE against non-internalizing pan-carcinoma marker TAG72
Ref 2	Tagworks pharmaceutical company product pipeline
Ref 3	Avibodie are engineered, bivalent antibody fragments, precisely loaded with imaging or cytotoxic payloads
Ref 4	Ortho-functionalized pyridinyl-tetrazines break the inverse correlation between click reactivity and cleavage yields in click-to-release chemistry