Antigen Information

General Information of This Antigen (ID: TAR0GDENB)
Antigen Name
Tumor-associated glycoprotein 72 (TAG-72)
Function
Tumor-associated glycoprotein 72 (TAG72) is a cell surface glycoprotein that functions similar to an MUC and is often overexpressed in and shed from pancreas cancer (PC). It is known to be a better prognostic indicator than CA19.9 or CEA. Despite this and the fact that Indium-111 satumomab pendetide, a derivative of the anti-TAG72 antibody B72.3, was the first monoclonal antibody to be approved for tumor imaging, other attempted applications of anti-TAG72 mAbs fizzled out.

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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-TAG-72 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TGW101 [1]
Monomethyl auristatin E
Microtubule (MT)
A cleavable linker
 ADC Info 
Anti-TAG-72 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TGW-101 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
ADC-AVP-04 [3]
Monomethyl auristatin E
Microtubule (MT)
Maleimide-functionalized TCO
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
anti-TAG-72 ADC [4]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
References
Ref 1 Preclinical development of TGW101, a first in class click-cleavable ADC with MMAE against non-internalizing pan-carcinoma marker TAG72
Ref 2 Tagworks pharmaceutical company product pipeline
Ref 3 Avibodie are engineered, bivalent antibody fragments, precisely loaded with imaging or cytotoxic payloads
Ref 4 Ortho-functionalized pyridinyl-tetrazines break the inverse correlation between click reactivity and cleavage yields in click-to-release chemistry