Antigen Information

General Information of This Antigen (ID: TAR0GAQGW)
Antigen Name
Ly6/PLAUR domain-containing protein 3 (LYPD3)
Gene Name
LYPD3
Gene ID
27076
Synonym
C4.4A; UNQ491; PRO1007; GPI-anchored metastasis-associated protein C4.4A homolog;Matrigel-induced gene C4 protein
Sequence
MDPARKAGAQAMIWTAGWLLLLLLRGGAQALECYSCVQKADDGCSPNKMKTVKCAPGVDV
CTEAVGAVETIHGQFSLAVRGCGSGLPGKNDRGLDLHGLLAFIQLQQCAQDRCNAKLNLT
SRALDPAGNESAYPPNGVECYSCVGLSREACQGTSPPVVSCYNASDHVYKGCFDGNVTLT
AANVTVSLPVRGCVQDEFCTRDGVTGPGFTLSGSCCQGSRCNSDLRNKTYFSPRIPPLVR
LPPPEPTTVASTTSVTTSTSAPVRPTSTTKPMPAPTSQTPRQGVEHEASRDEEPRLTGGA
AGHQDRSNSGQYPAKGGPQQPHNKGCVAPTAGLAALLLAVAAGVLL

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Function
Supports cell migration. May be involved in urothelial cell- matrix interactions. May be involved in tumor progression.

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Uniprot Entry
LYPD3_HUMAN
HGNC ID
HGNC:24880
KEGG ID
hsa:27076
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-human CD276 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
C4.4A-EC3 [1]
NAMPT inhibitor 4
Nicotinamide phosphoribosyltransferase (NAMPT)
Mc-Val-Ala
 ADC Info 
Anti-human LYPD3 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
C4.4A-EC4 [1]
NAMPT inhibitor 5
Nicotinamide phosphoribosyltransferase (NAMPT)
Open-chain glycine maleimide
 ADC Info 
C4.4A-EC5 [2]
NAMPT inhibitor 6
Nicotinamide phosphoribosyltransferase (NAMPT)
Open-chain glycine maleimide-PEG
 ADC Info 
C4.4A-EC2 [1]
NAMPT inhibitor 6
Nicotinamide phosphoribosyltransferase (NAMPT)
Maleimido-caproyl
 ADC Info 
C4.4A-EC1 [1]
NAMPT inhibitor 4
Nicotinamide phosphoribosyltransferase (NAMPT)
Maleimido-caproyl
 ADC Info 
Lupartumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Lupartumab amadotin
Auristatin W derivative
Microtubule (MT)
Mc-hydrazide linker
 ADC Info 
References
Ref 1 A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy. Bioconjug Chem. 2022 Jun 15;33(6):1210-1221.
Ref 2 Taxol(r) structure-activity-relationships - synthesis and biological evaluation of taxol analogs modified at c-7. Bioorg Med Chem Lett. 1994;4(18):2223-2228.