Antigen Information

General Information of This Antigen
Antigen ID
TAR0GAQGW
Antigen Name
Ly6/PLAUR domain-containing protein 3 (LYPD3)
Gene Name
LYPD3
Synonym
C4.4A; UNQ491; PRO1007; GPI-anchored metastasis-associated protein C4.4A homolog;Matrigel-induced gene C4 protein
Sequence
MDPARKAGAQAMIWTAGWLLLLLLRGGAQALECYSCVQKADDGCSPNKMKTVKCAPGVDV
CTEAVGAVETIHGQFSLAVRGCGSGLPGKNDRGLDLHGLLAFIQLQQCAQDRCNAKLNLT
SRALDPAGNESAYPPNGVECYSCVGLSREACQGTSPPVVSCYNASDHVYKGCFDGNVTLT
AANVTVSLPVRGCVQDEFCTRDGVTGPGFTLSGSCCQGSRCNSDLRNKTYFSPRIPPLVR
LPPPEPTTVASTTSVTTSTSAPVRPTSTTKPMPAPTSQTPRQGVEHEASRDEEPRLTGGA
AGHQDRSNSGQYPAKGGPQQPHNKGCVAPTAGLAALLLAVAAGVLL

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Function
Supports cell migration. May be involved in urothelial cell- matrix interactions. May be involved in tumor progression.

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Uniprot Entry
LYPD3_HUMAN
HGNC ID
HGNC:24880
KEGG ID
hsa:27076
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-human CD276 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
C4.4A-EC3
NAMPT inhibitor 4
Nicotinamide phosphoribosyltransferase (NAMPT)
Mc-Val-Ala
 [1]
Anti-human LYPD3 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
C4.4A-EC4
NAMPT inhibitor 5
Nicotinamide phosphoribosyltransferase (NAMPT)
Open-chain glycine maleimide
 [1]
 ADC Info 
C4.4A-EC5
NAMPT inhibitor 6
Nicotinamide phosphoribosyltransferase (NAMPT)
Open-chain glycine maleimide-PEG
 [2]
 ADC Info 
C4.4A-EC2
NAMPT inhibitor 6
Nicotinamide phosphoribosyltransferase (NAMPT)
Maleimido-caproyl
 [1]
 ADC Info 
C4.4A-EC1
NAMPT inhibitor 4
Nicotinamide phosphoribosyltransferase (NAMPT)
Maleimido-caproyl
 [1]
Lupartumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Lupartumab amadotin
Auristatin W derivative
Microtubule (MT)
Mc-hydrazide linker
References
Ref 1 A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy. Bioconjug Chem. 2022 Jun 15;33(6):1210-1221.
Ref 2 Taxol(r) structure-activity-relationships - synthesis and biological evaluation of taxol analogs modified at c-7. Bioorg Med Chem Lett. 1994;4(18):2223-2228.