Antigen Information

General Information of This Antigen (ID: TAR0FIJGT)
Antigen Name
Prolactin receptor (PRLR)
Gene Name
PRLR
Gene ID
11156
Sequence
MKENVASATVFTLLLFLNTCLLNGQLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNY
SLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVD
VTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEW
EIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMNDTTVWIS
VAVLSAVICLIIVWAVALKGYSMVTCIFPPVPGPKIKGFDAHLLEKGKSEELLSALGCQD
FPPTSDYEDLLVEYLEVDDSEDQHLMSVHSKEHPSQGMKPTYLDPDTDSGRGSCDSPSLL
SEKCEEPQANPSTFYDPEVIEKPENPETTHTWDPQCISMEGKIPYFHAGGSKCSTWPLPQ
PSQHNPRSSYHNITDVCELAVGPAGAPATLLNEAGKDALKSSQTIKSREEGKATQQREVE
SFHSETDQDTPWLLPQEKTPFGSAKPLDYVEIHKVNKDGALSLLPKQRENSGKPKKPGTP
ENNKEYAKVSGVMDNNILVLVPDPHAKNVACFEESAKEAPPSLEQNQAEKALANFTATSS
KCRLQLGGLDYLDPACFTHSFH

    Click to Show/Hide
Family
Cytokine receptor type I family
Function
This is a receptor for the anterior pitui.y hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.

    Click to Show/Hide
Uniprot Entry
PRLR_HUMAN
HGNC ID
HGNC:9446
KEGG ID
hsa:5618
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-PRLR mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-PRLR-Ab-LP2-P12 [1]
Budesonide derivative P12
Glucocorticoid receptor (NR3C1)
DIBAC-suc-PEG4-Val-Cit-PAB
 ADC Info 
Anti-PRLR-Ab-LP1-P3 [1]
Budesonide derivative P3
Glucocorticoid receptor (NR3C1)
DIBAC-suc-PEG4-Val-Cit-PAB
 ADC Info 
PRLR-16 [2]
DM1 derivative 16
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
REGN2878-DM1 [3]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
Rolinsatamab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Rolinsatamab talirine
SGD-1882
Human deoxyribonucleic acid (hDNA)
Mc-Val-Ala
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-PRLR antibody drug conjugate [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Development of Novel Glucocorticoids for Use in Antibody-Drug Conjugates for the Treatment of Inflammatory Diseases. J Med Chem. 2021 Aug 26;64(16):11958-11971. doi: 10.1021/acs.jmedchem.1c00541. Epub 2021 Aug 11.
Ref 2 Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids. Bioorg Med Chem. 2018 May 15;26(9):2271-2279. doi: 10.1016/j.bmc.2018.02.025. Epub 2018 Feb 21.
Ref 3 Preclinical Activity of the Novel Anti-Prolactin Receptor (PRLR) Antibody-Drug Conjugate REGN2878-DM1 in PRLR-Positive Breast Cancers. Mol Cancer Ther. 2017 Jul;16(7):1299-1311. doi: 10.1158/1535-7163.MCT-16-0839. Epub 2017 Apr 4.
Ref 4 Introduction to basic information on anti PRLR antibody drug-conjugates(Regeneron Pharmaceuticals).