Antigen Information

General Information of This Antigen
Antigen ID
TAR0FIJGT
Antigen Name
Prolactin receptor (PRLR)
Gene Name
PRLR
Sequence
MKENVASATVFTLLLFLNTCLLNGQLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNY
SLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVD
VTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEW
EIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMNDTTVWIS
VAVLSAVICLIIVWAVALKGYSMVTCIFPPVPGPKIKGFDAHLLEKGKSEELLSALGCQD
FPPTSDYEDLLVEYLEVDDSEDQHLMSVHSKEHPSQGMKPTYLDPDTDSGRGSCDSPSLL
SEKCEEPQANPSTFYDPEVIEKPENPETTHTWDPQCISMEGKIPYFHAGGSKCSTWPLPQ
PSQHNPRSSYHNITDVCELAVGPAGAPATLLNEAGKDALKSSQTIKSREEGKATQQREVE
SFHSETDQDTPWLLPQEKTPFGSAKPLDYVEIHKVNKDGALSLLPKQRENSGKPKKPGTP
ENNKEYAKVSGVMDNNILVLVPDPHAKNVACFEESAKEAPPSLEQNQAEKALANFTATSS
KCRLQLGGLDYLDPACFTHSFH

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Family
Cytokine receptor type I family
Function
This is a receptor for the anterior pitui.y hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.

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Uniprot Entry
PRLR_HUMAN
HGNC ID
HGNC:9446
KEGG ID
hsa:5618
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-PRLR mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-PRLR-Ab-LP2-P12
Budesonide derivative P12
Glucocorticoid receptor (NR3C1)
DIBAC-suc-PEG4-Val-Cit-PAB
 [1]
 ADC Info 
Anti-PRLR-Ab-LP1-P3
Budesonide derivative P3
Glucocorticoid receptor (NR3C1)
DIBAC-suc-PEG4-Val-Cit-PAB
 [1]
 ADC Info 
PRLR-16
DM1 derivative 16
Microtubule (MT)
Mc-Val-Cit-PABC
 [2]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
REGN2878-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [3]
Rolinsatamab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Rolinsatamab talirine
SGD-1882
Human deoxyribonucleic acid (hDNA)
Mc-Val-Ala
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-PRLR antibody drug conjugate
Undisclosed
Undisclosed
Undisclosed
 [4]
References
Ref 1 Development of Novel Glucocorticoids for Use in Antibody-Drug Conjugates for the Treatment of Inflammatory Diseases. J Med Chem. 2021 Aug 26;64(16):11958-11971. doi: 10.1021/acs.jmedchem.1c00541. Epub 2021 Aug 11.
Ref 2 Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids. Bioorg Med Chem. 2018 May 15;26(9):2271-2279. doi: 10.1016/j.bmc.2018.02.025. Epub 2018 Feb 21.
Ref 3 Preclinical Activity of the Novel Anti-Prolactin Receptor (PRLR) Antibody-Drug Conjugate REGN2878-DM1 in PRLR-Positive Breast Cancers. Mol Cancer Ther. 2017 Jul;16(7):1299-1311. doi: 10.1158/1535-7163.MCT-16-0839. Epub 2017 Apr 4.
Ref 4 Introduction to basic information on anti PRLR antibody drug-conjugates(Regeneron Pharmaceuticals).