Antigen Information

General Information of This Antigen (ID: TAR0FBZTE)
Antigen Name
Endosialin (CD248)
Gene Name
CD248
Gene ID
57124
Synonym
CD164L1; TEM1; Tumor endothelial marker 1;CD248
Sequence
MLLRLLLAWAAAGPTLGQDPWAAEPRAACGPSSCYALFPRRRTFLEAWRACRELGGDLAT
PRTPEEAQRVDSLVGAGPASRLLWIGLQRQARQCQLQRPLRGFTWTTGDQDTAFTNWAQP
ASGGPCPAQRCVALEASGEHRWLEGSCTLAVDGYLCQFGFEGACPALQDEAGQAGPAVYT
TPFHLVSTEFEWLPFGSVAAVQCQAGRGASLLCVKQPEGGVGWSRAGPLCLGTGCSPDNG
GCEHECVEEVDGHVSCRCTEGFRLAADGRSCEDPCAQAPCEQQCEPGGPQGYSCHCRLGF
RPAEDDPHRCVDTDECQIAGVCQQMCVNYVGGFECYCSEGHELEADGISCSPAGAMGAQA
SQDLGDELLDDGEDEEDEDEAWKAFNGGWTEMPGILWMEPTQPPDFALAYRPSFPEDREP
QIPYPEPTWPPPLSAPRVPYHSSVLSVTRPVVVSATHPTLPSAHQPPVIPATHPALSRDH
QIPVIAANYPDLPSAYQPGILSVSHSAQPPAHQPPMISTKYPELFPAHQSPMFPDTRVAG
TQTTTHLPGIPPNHAPLVTTLGAQLPPQAPDALVLRTQATQLPIIPTAQPSLTTTSRSPV
SPAHQISVPAATQPAALPTLLPSQSPTNQTSPISPTHPHSKAPQIPREDGPSPKLALWLP
SPAPTAAPTALGEAGLAEHSQRDDRWLLVALLVPTCVFLVVLLALGIVYCTRCGPHAPNK
RITDCYRWVIHAGSKSPTEPMPPRGSLTGVQTCRTSV

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Function
May play a role in tumor angiogenesis.

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Uniprot Entry
CD248_HUMAN
HGNC ID
HGNC:18219
KEGG ID
hsa:57124
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-CD248 mAb hMP-E-8.3
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ENDOS/ADC [1]
Duocarmycin derivative
Human Deoxyribonucleic acid (hDNA)
Val-Cit
 ADC Info 
Anti-CD248 mAb IgG78
 Antibody Info 
ADC Name Payload Target Linker ADC Info
IgG78-DM1 [2]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
Anti-TEM1 mAb Clone 187 A114N
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TEM1 Clone 187 A114N-Mc-Val-Cit-PABC-MMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-TEM1 mAb Clone 187 WT
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TEM1 Clone 187 WT-Mc-Val-Cit-PABC-MMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Ontuxizumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Ontuxizumab-Compound (Ia) [4]
NeoDegrader P1
Protein cereblon (CRBN)
Ontuxizumab-Compound (Ia) linker
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-endosialin-Mc-Val-Cit-PABC-MMAE [5]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
MP-ENDOS-ADC [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Generation of a novel Antibody-Drug Conjugate targeting endosialin: potent and durable antitumor response in sarcoma. Oncotarget. 2017 Jul 22;8(36):60368-60377. doi: 10.18632/oncotarget.19499. eCollection 2017 Sep 1.
Ref 2 Antibody-drug conjugates targeting CD248(+) myofibroblasts effectively alleviate renal fibrosis in mice. FASEB J. 2022 Feb;36(2):e22102. doi: 10.1096/fj.202101441R.
Ref 3 Site-specific antibody-drug conjugation through glycoengineering.
Ref 4 Neodegrader conjugates; 2021-10-07.
Ref 5 Anti-Endosialin Antibody-Drug Conjugate: Potential in Sarcoma and Other Malignancies. Mol Cancer Ther. 2015 Sep;14(9):2081-9. doi: 10.1158/1535-7163.MCT-15-0312. Epub 2015 Jul 16.
Ref 6 Generation of a novel Antibody-Drug Conjugate targeting endosialin: potent and durable antitumor response in sarcoma. Oncotarget. 2017 Jul 22;8(36):60368-60377. doi: 10.18632/oncotarget.19499.