Antigen Information

General Information of This Antigen
Antigen ID
TAR0FBZTE
Antigen Name
Endosialin (CD248)
Gene Name
CD248
Synonym
CD164L1; TEM1; Tumor endothelial marker 1;CD_antigen=CD248
Sequence
MLLRLLLAWAAAGPTLGQDPWAAEPRAACGPSSCYALFPRRRTFLEAWRACRELGGDLAT
PRTPEEAQRVDSLVGAGPASRLLWIGLQRQARQCQLQRPLRGFTWTTGDQDTAFTNWAQP
ASGGPCPAQRCVALEASGEHRWLEGSCTLAVDGYLCQFGFEGACPALQDEAGQAGPAVYT
TPFHLVSTEFEWLPFGSVAAVQCQAGRGASLLCVKQPEGGVGWSRAGPLCLGTGCSPDNG
GCEHECVEEVDGHVSCRCTEGFRLAADGRSCEDPCAQAPCEQQCEPGGPQGYSCHCRLGF
RPAEDDPHRCVDTDECQIAGVCQQMCVNYVGGFECYCSEGHELEADGISCSPAGAMGAQA
SQDLGDELLDDGEDEEDEDEAWKAFNGGWTEMPGILWMEPTQPPDFALAYRPSFPEDREP
QIPYPEPTWPPPLSAPRVPYHSSVLSVTRPVVVSATHPTLPSAHQPPVIPATHPALSRDH
QIPVIAANYPDLPSAYQPGILSVSHSAQPPAHQPPMISTKYPELFPAHQSPMFPDTRVAG
TQTTTHLPGIPPNHAPLVTTLGAQLPPQAPDALVLRTQATQLPIIPTAQPSLTTTSRSPV
SPAHQISVPAATQPAALPTLLPSQSPTNQTSPISPTHPHSKAPQIPREDGPSPKLALWLP
SPAPTAAPTALGEAGLAEHSQRDDRWLLVALLVPTCVFLVVLLALGIVYCTRCGPHAPNK
RITDCYRWVIHAGSKSPTEPMPPRGSLTGVQTCRTSV

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Function
May play a role in tumor angiogenesis.

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Uniprot Entry
CD248_HUMAN
HGNC ID
HGNC:18219
KEGG ID
hsa:57124
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-CD248 mAb hMP-E-8.3
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ENDOS/ADC
Duocarmycin derivative
Human Deoxyribonucleic acid (hDNA)
Val-Cit
 [1]
Anti-CD248 mAb IgG78
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
IgG78-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [2]
Anti-TEM1 mAb Clone 187 A114N
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
TEM1 Clone 187 A114N-Mc-Val-Cit-PABC-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [3]
Anti-TEM1 mAb Clone 187 WT
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
TEM1 Clone 187 WT-Mc-Val-Cit-PABC-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [3]
Ontuxizumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Ontuxizumab-Compound (Ia)
NeoDegrader P1
Protein cereblon (CRBN)
Ontuxizumab-Compound (Ia) linker
 [4]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-endosialin-Mc-Val-Cit-PABC-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [5]
 ADC Info 
MP-ENDOS-ADC
Undisclosed
Undisclosed
Undisclosed
 [6]
References
Ref 1 Generation of a novel Antibody-Drug Conjugate targeting endosialin: potent and durable antitumor response in sarcoma. Oncotarget. 2017 Jul 22;8(36):60368-60377. doi: 10.18632/oncotarget.19499. eCollection 2017 Sep 1.
Ref 2 Antibody-drug conjugates targeting CD248(+) myofibroblasts effectively alleviate renal fibrosis in mice. FASEB J. 2022 Feb;36(2):e22102. doi: 10.1096/fj.202101441R.
Ref 3 Site-specific antibody-drug conjugation through glycoengineering.
Ref 4 Neodegrader conjugates; 2021-10-07.
Ref 5 Anti-Endosialin Antibody-Drug Conjugate: Potential in Sarcoma and Other Malignancies. Mol Cancer Ther. 2015 Sep;14(9):2081-9. doi: 10.1158/1535-7163.MCT-15-0312. Epub 2015 Jul 16.
Ref 6 Generation of a novel Antibody-Drug Conjugate targeting endosialin: potent and durable antitumor response in sarcoma. Oncotarget. 2017 Jul 22;8(36):60368-60377. doi: 10.18632/oncotarget.19499.