Antigen Information

General Information of This Antigen (ID: TAR0BIRRP)
Antigen Name
Receptor-type tyrosine-protein kinase FLT3 (FLT3)
Gene Name
FLT3
Gene ID
2322
Synonym
CD135; FLK2; STK1; FL cytokine receptor;Fetal liver kinase-2;Fms-like tyrosine kinase 3;Stem cell tyrosine kinase 1;CD135
Sequence
MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESP
EDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDL
QNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQD
ALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRE
CTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEM
STYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYE
IDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHA
ENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITE
GVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQD
NISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYD
LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMS
ELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKE
HNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDL
NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDS
NYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYK
LIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDG
RVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS

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Family
Tyr protein family
Function
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

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Uniprot Entry
FLT3_HUMAN
HGNC ID
HGNC:3765
KEGG ID
hsa:2322
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
39870768 20D9h3-DUBA [1]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 ADC Info 
39870768 20D9h3-MMAF [1]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
Anti-FLT3 IgG1κ mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AGS62P1
AGD-0182
Microtubule (MT)
Alkoxyamine linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
IGAC-95 [2]
IG-L-18 Payload
Undisclosed
IG-L-25 linker
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2024043319A1 79 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CN119630431A ADC-91 [4]
CN119630431A-ADC-82-PAYLOAD
Undisclosed
CN119630431A-ADC-82-LINKER
 ADC Info 
References
Ref 1 Effective eradication of acute myeloid leukemia stem cells with FLT3-directed antibody-drug conjugates
Ref 2 Isoindolinone-glutarimide antibody conjugates, and uses thereof
Ref 3 Antibody-drug complexes
Ref 4 Antibody-drug conjugates