LYADC000464
     RDKit          3D

150160  0  0  1  0  0  0  0  0999 V2000
    2.2239    3.0119    6.8443 C   0  0  0  0  0  2  0  0  0  0  0  0
    1.3486    0.1385   10.2046 C   0  0  0  0  0  2  0  0  0  0  0  0
    2.3206   -1.6533    9.7519 C   0  0  0  0  0  2  0  0  0  0  0  0
    1.9896    2.9535    8.3536 C   0  0  0  0  0  2  0  0  0  0  0  0
    1.6254    1.6543    9.9731 C   0  0  0  0  0  2  0  0  0  0  0  0
    3.7094   -2.1622    9.2921 C   0  0  0  0  0  2  0  0  0  0  0  0
    5.5420   -2.8164   10.2586 C   0  0  0  0  0  1  0  0  0  0  0  0
    1.9161    4.0580    4.9901 C   0  0  0  0  0  2  0  0  0  0  0  0
    1.4953    7.1062    1.2293 C   0  0  0  0  0  2  0  0  0  0  0  0
    1.8866    6.7387   -0.9219 C   0  0  0  0  0  2  0  0  0  0  0  0
    1.5294    2.4258   -3.2215 C   0  0  0  0  0  2  0  0  0  0  0  0
    1.1986    5.2424    4.2874 C   0  0  0  0  0  2  0  0  0  0  0  0
    0.9899    6.5575    2.5819 C   0  0  0  0  0  2  0  0  0  0  0  0
    2.0985    5.7678   -2.1400 C   0  0  0  0  0  2  0  0  0  0  0  0
    1.9504    3.9169   -3.2417 C   0  0  0  0  0  2  0  0  0  0  0  0
    3.6131   -4.1445    4.9539 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9529   -3.2496    3.8303 C   0  0  0  0  0  2  0  0  0  0  0  0
   -0.2105   -2.3912    2.2371 C   0  0  0  0  0  2  0  0  0  0  0  0
   -2.1361   -0.3845   -1.7427 C   0  0  0  0  0  2  0  0  0  0  0  0
   -2.6768   -0.0706   -3.7813 C   0  0  0  0  0  2  0  0  0  0  0  0
    0.9025    0.6179   -4.3033 C   0  0  0  0  0  2  0  0  0  0  0  0
   -5.6118    0.2494    2.1257 C   0  0  0  0  0  2  0  0  0  0  0  0
    2.3562   -3.6716    4.3642 C   0  0  0  0  0  2  0  0  0  0  0  0
   -0.0694   -1.6616    0.8715 C   0  0  0  0  0  2  0  0  0  0  0  0
   -0.8740   -0.6456   -0.8756 C   0  0  0  0  0  2  0  0  0  0  0  0
   -1.9509    0.0751   -5.1558 C   0  0  0  0  0  2  0  0  0  0  0  0
    0.0410    0.2456   -5.5199 C   0  0  0  0  0  2  0  0  0  0  0  0
   -7.2780   -7.5648    7.0165 C   0  0  0  0  0  3  0  0  0  0  0  0
   -6.4974   -0.8464    1.9317 C   0  0  0  0  0  3  0  0  0  0  0  0
   -6.7398    0.3092    1.1266 C   0  0  0  0  0  2  0  0  0  0  0  0
    5.4453   -2.7913    5.2617 C   0  0  0  0  0  2  0  0  0  0  0  0
   -7.7592   -5.2022    1.9732 C   0  0  0  0  0  3  0  0  0  0  0  0
   -9.0347   -5.7621    2.0733 C   0  0  0  0  0  3  0  0  0  0  0  0
   -6.4911   -6.7579    6.2073 C   0  0  0  0  0  3  0  0  0  0  0  0
    6.6246   -1.9476    4.6210 C   0  0  0  0  0  2  0  0  0  0  0  0
   -5.2970   -8.3835    7.1978 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0883   -9.2058    7.5927 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2000   -3.2224    2.0691 C   0  0  1  0  0  0  0  0  0  0  0  0
   -5.2485   -7.3003    6.2725 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6045   -3.8329    1.8055 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.1480   -4.9117    1.9888 C   0  0  0  0  0  3  0  0  0  0  0  0
   -6.1486   -2.9671    3.5548 C   0  0  0  0  0  2  0  0  0  0  0  0
    7.5019   -0.8603    3.9420 C   0  0  0  0  0  2  0  0  0  0  0  0
   -8.7370   -3.0287    1.6373 C   0  0  0  0  0  3  0  0  0  0  0  0
  -10.0070   -3.5740    1.6515 C   0  0  0  0  0  3  0  0  0  0  0  0
    8.0538    0.2843    3.0589 C   0  0  0  0  0  2  0  0  0  0  0  0
   -3.8911   -6.8728    5.5692 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4828   -5.4135    3.5684 C   0  0  0  0  0  3  0  0  0  0  0  0
   -5.1256   -4.1871    1.4665 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5109   -9.1826    7.1083 C   0  0  0  0  0  1  0  0  0  0  0  0
   -2.9957   -7.5932    6.1531 C   0  0  0  0  0  3  0  0  0  0  0  0
   -3.7157   -6.4364    4.1525 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3880   -5.1559    2.1761 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9234    2.8418   -0.0987 C   0  0  0  0  0  2  0  0  0  0  0  0
    4.7144    1.6760   -1.2300 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2034    1.2485    2.0063 C   0  0  0  0  0  3  0  0  0  0  0  0
    9.4844    1.9792   -2.6583 C   0  0  0  0  0  2  0  0  0  0  0  0
    8.6384    3.5280    1.5700 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1318    2.5187   -0.7665 C   0  0  0  0  0  2  0  0  0  0  0  0
    5.4715    0.5544   -5.0261 C   0  0  0  0  0  2  0  0  0  0  0  0
    4.2938   -1.5809   -5.3358 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7932   -7.1115    3.3502 C   0  0  0  0  0  3  0  0  0  0  0  0
   -4.2605   -5.0064   -0.5603 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4848   -4.3955   -2.8122 C   0  0  0  0  0  2  0  0  0  0  0  0
    1.5559    3.1899    0.3065 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0028    0.9322   -0.8954 C   0  0  0  0  0  3  0  0  0  0  0  0
    7.7877    0.6768    0.6069 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4844   -5.8746    1.4020 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4113    3.2205    0.3936 C   0  0  0  0  0  2  0  0  0  0  0  0
    8.1737    2.2847   -3.4589 C   0  0  0  0  0  2  0  0  0  0  0  0
    6.3095    1.7262   -4.4508 C   0  0  0  0  0  2  0  0  0  0  0  0
    4.5240   -2.6188   -6.4034 C   0  0  0  0  0  3  0  0  0  0  0  0
   -3.8562   -3.4639   -4.0319 C   0  0  0  0  0  2  0  0  0  0  0  0
   -2.6839   -6.8059    1.9974 C   0  0  0  0  0  3  0  0  0  0  0  0
    6.1716   -0.3397   -1.5433 C   0  0  0  0  0  2  0  0  0  0  0  0
    5.2013   -0.5452   -7.1291 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8409   -4.9618   -6.8608 C   0  0  0  0  0  1  0  0  0  0  0  0
    5.0866   -1.9608   -7.5048 C   0  0  0  0  0  3  0  0  0  0  0  0
   -5.7419   -4.8460   -2.5444 C   0  0  0  0  0  2  0  0  0  0  0  0
   -5.1788   -3.2155   -4.5507 C   0  0  0  0  0  3  0  0  0  0  0  0
   -6.8490   -1.8771   -5.7467 C   0  0  0  0  0  2  0  0  0  0  0  0
   -0.6949    3.1049   -0.2307 C   0  0  0  0  0  2  0  0  0  0  0  0
    6.2422   -1.5827   -2.2404 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1341   -3.9275   -3.7494 C   0  0  0  0  0  2  0  0  0  0  0  0
   -7.3248   -1.5272   -7.1876 C   0  0  0  0  0  2  0  0  0  0  0  0
   -2.2574    3.9616   -1.9021 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7243   -1.5618   -6.2739 C   0  0  0  0  0  2  0  0  0  0  0  0
   -6.4449   -1.0312   -8.3189 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9798    1.3665   -7.9099 C   0  0  0  0  0  2  0  0  0  0  0  0
   -2.0168    4.9959    0.4126 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1940   -1.4461  -10.0106 C   0  0  0  0  0  1  0  0  0  0  0  0
   -5.0772   -1.2420   -7.7732 C   0  0  0  0  0  2  0  0  0  0  0  0
   -5.2244    2.4497   -7.0934 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2583    6.2894   -0.1789 C   0  0  0  0  0  2  0  0  0  0  0  0
   -6.7144   -1.8979   -9.6248 C   0  0  0  0  0  1  0  0  0  0  0  0
   -4.7066    3.3415   -6.4605 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5589    4.3205   -4.4992 C   0  0  0  0  0  3  0  0  0  0  0  0
   -4.1065    4.4450   -5.7833 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0722    5.4466   -3.7830 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4880    6.3363   -1.6393 C   0  0  0  0  0  2  0  0  0  0  0  0
   -4.1048    5.6863   -6.4213 C   0  0  0  0  0  3  0  0  0  0  0  0
   -3.1104    6.6840   -4.4487 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5922    6.7961   -5.7768 C   0  0  0  0  0  3  0  0  0  0  0  0
   -2.2656    8.9093   -4.6054 C   0  0  0  0  0  1  0  0  0  0  0  0
    1.8998    2.9095    9.6811 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9458   -2.5440    8.9884 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5476    3.0302    5.5482 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1897   -1.1645   10.2520 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3959    6.0933    3.6700 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4189    5.1647   -3.2763 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9600   -5.3112    4.7320 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8015    7.6587    0.0493 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2109    1.1338   -3.0979 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2390   -1.0183   -0.2376 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1069    0.0962   -6.2092 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1882   -3.3090    5.7926 N   0  0  0  0  0  2  0  0  0  0  0  0
   -0.2978   -3.0722    3.3833 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1899   -0.2572   -2.5576 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5740   -8.5581    7.6004 N   0  0  0  0  0  3  0  0  0  0  0  0
   -6.0258   -1.9966    1.3200 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3887   -2.7016    4.9264 O   0  0  0  0  0  1  0  0  0  0  0  0
   -4.0301  -10.1971    8.3209 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9022   -8.6544    6.9750 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0866    1.3137   -2.2303 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4539    4.7235    1.8229 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5670   -1.7540   -4.3753 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9770    1.4684   -0.1148 N   0  0  0  0  0  2  0  0  0  0  0  0
   -5.0767   -4.1580    0.0894 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4248    4.2412    0.9459 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0733    2.7405   -4.0640 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3632    2.6436   -0.3647 N   0  0  0  0  0  2  0  0  0  0  0  0
    8.4271    2.5079    2.4324 N   0  0  0  0  0  2  0  0  0  0  0  0
   10.5321    1.8242   -1.8455 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9977   -0.4757   -5.7625 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4950   -4.2550   -5.8947 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4176   -5.8102    0.0747 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3950   -5.2049   -1.9522 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5840    2.3424   -0.0364 N   0  0  0  0  0  2  0  0  0  0  0  0
    8.2349   -0.4883    0.3757 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6737   -1.6832   -3.4014 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3799    0.3846   -7.9082 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5321   -1.8955   -5.0504 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1969   -2.6074   -9.0871 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4953    2.9052   -2.5031 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6584    4.0112   -0.5522 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2920    4.8611    1.5972 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7221   -2.7978   -1.6081 N   0  0  0  0  0  1  0  0  0  0  0  0
   -6.7836    0.3823   -8.6275 N   0  0  0  0  0  2  0  0  0  0  0  0
   -2.5870    5.2658   -2.4520 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7190    7.8322   -3.7898 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  4  1  0
  1107  1  0
  2  5  1  0
  2108  1  0
  3  6  1  0
  3108  1  0
  4105  1  0
  5105  1  0
  6106  1  0
  7106  1  0
  8 12  1  0
  8107  1  0
  9 13  1  0
  9112  1  0
 10 14  1  0
 10112  1  0
 11 15  1  0
 11113  1  0
 12109  1  0
 13109  1  0
 14110  1  0
 15110  1  0
 16 23  1  0
 16111  2  0
 16116  1  0
 17 23  1  0
 17117  1  0
 18 24  1  0
 18117  1  0
 19 25  1  0
 19118  1  0
 20 26  1  0
 20118  1  0
 21 27  1  0
 21113  1  0
 22 29  1  0
 22 30  1  0
 24114  1  0
 25114  1  0
 26115  1  0
 27115  1  0
 28 34  2  0
 28119  1  0
 29 30  1  0
 29120  1  0
 31 35  1  0
 31116  1  0
 32 33  2  0
 32 40  1  0
 33 41  1  0
 34 39  1  0
 35 43  1  0
 36 37  1  0
 36 39  2  0
 36119  1  0
 37122  2  0
 37123  1  0
 38 40  1  0
 38 42  1  1
 38 49  1  0
 38120  1  0
 39 47  1  0
 40 44  2  0
 41 45  2  0
 42121  1  0
 43 46  1  0
 44 45  1  0
 47 51  2  0
 47 52  1  0
 48 52  2  0
 48 53  1  0
 49 53  2  0
 49128  1  0
 50123  1  0
 51123  1  0
 52 62  1  0
 53 68  1  0
 54 65  1  0
 54131  1  0
 55 66  1  0
 55124  2  0
 55131  1  0
 56 46  1  0
 56 67  1  0
 56132  1  0
 57 70  1  0
 57133  1  0
 58 69  1  0
 58125  2  0
 58132  1  0
 59 69  1  0
 59133  1  0
 60 71  1  0
 60134  1  0
 61 72  1  0
 61126  2  0
 61134  1  0
 62 74  2  0
 63128  2  0
 63136  1  0
 63137  1  0
 64 73  1  0
 64137  1  0
 65129  2  0
 65138  1  0
 66 75  1  0
 66127  1  0
 67127  1  0
 67139  2  0
 68 74  1  0
 68136  2  0
 70130  1  0
 71130  1  0
 72 78  1  0
 72135  1  0
 73 80  1  0
 75 83  1  0
 76 78  1  0
 76134  1  0
 76141  2  0
 77135  1  0
 78143  1  0
 79 84  1  0
 79137  1  0
 80 84  1  0
 80142  1  0
 81 85  1  0
 81142  1  0
 82138  1  0
 82145  1  0
 83140  2  0
 83147  1  0
 85 88  1  0
 86144  2  0
 86145  1  0
 86149  1  0
 87 92  1  0
 87142  1  0
 88 92  1  0
 88 95  1  0
 88148  1  0
 89 93  1  0
 89148  1  0
 90 94  1  0
 90145  1  0
 90146  2  0
 91143  1  0
 93 96  3  0
 94100  1  0
 96 98  1  0
 97 98  2  0
 97 99  1  0
 98101  1  0
 99102  2  0
 99149  1  0
100149  1  0
101103  2  0
102103  1  0
102150  1  0
104150  1  0
M  RAD  8   1   3   2   3   3   3   4   3   5   3   6   3   7   2   8   3
M  RAD  8   9   3  10   3  11   3  12   3  13   3  14   3  15   3  17   3
M  RAD  8  18   3  19   3  20   3  21   3  22   3  23   3  24   3  25   3
M  RAD  8  26   3  27   3  28   2  29   2  30   3  31   3  32   2  33   2
M  RAD  8  34   2  35   3  41   2  42   3  43   3  44   2  45   2  46   3
M  RAD  8  48   2  50   2  51   2  54   3  56   2  57   3  59   3  60   3
M  RAD  8  62   2  64   3  66   2  69   3  70   3  71   3  72   2  73   3
M  RAD  8  74   2  75   3  77   2  78   2  79   3  80   2  81   3  82   3
M  RAD  8  84   3  85   3  87   3  89   3  91   2  92   3  94   3  95   2
M  RAD  8  97   2 100   3 101   2 103   2 104   2 116   2 119   2 121   2
M  RAD  6 127   2 131   2 132   2 138   2 147   3 148   2
M  END
$$$$
