Target Information

General Information of This Target
Target ID
PTAR0OLMUY
Target Name
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Gene Name
MCL1; BCL2L3
Gene ID
4170
Synonym
BCL2L3
Sequence
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR

    Click to Show/Hide
Family
Bcl-2 family
Function
FUNCTION: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. {ECO:0000269|PubMed:10766760, ECO:0000269|PubMed:16543145}.

    Click to Show/Hide
Uniprot Entry
MCL1_HUMAN
HGNC ID
HGNC:6943
KEGG ID
hsa:4170
Full List of The ADC Related to This Target
Phase 1/2 (discontinued)
Click To Hide/Show 1 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
ADC Info
S227928
Anti-CD74 antibody
CD74
S64315 (MIK665)
Val-Cit-(PEG24) linker