Target Information
General Information of This Target (ID: PTAR0OLMUY)
| Target Name | Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) |
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| Gene Name | MCL1; BCL2L3 |
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| Gene ID | ||||||
| Synonym | BCL2L3 |
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| Sequence |
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR Click to Show/Hide
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| Family | Bcl-2 family |
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| Function |
FUNCTION: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. {ECO:0000269|PubMed:10766760, ECO:0000269|PubMed:16543145}.
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Full List of The ADC Related to This Target
Phase 1/2 (discontinued)
| ADC Name | Antibody | Antigen | Payload | Linker | ADC Info |
|---|---|---|---|---|---|
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S227928
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Anti-CD74 antibody |
HLA class II histocompatibility antigen gamma chain (CD74) |
S64315 (MIK665) |
Val-Cit-(PEG24) linker |