Target Information

General Information of This Target (ID: PAYTAR0GLHTL)

Target Name	Microtubule (MT)+DNA topoisomerase 1 (TOP1)

Full List of The ADC Related to This Target

Phase 1

Click To Hide/Show 1 ADC Related to This Stage

ADC Name	Antibody	Antigen	Payload	Linker	ADC Info
IBI3020 ^[1]	Anti-CEACAM5 antibody	Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)	MMAE; TOP1 inhibitor	A cleavable linker	ADC Info

Phase 1

Click To Hide/Show 1 ADC Related to This Stage

ADC Name	Antibody	Antigen	Payload	Linker	ADC Info
IBI3028	Anti-EGFR/c-Met bsAb	Hepatocyte growth factor receptor (MET); Epidermal growth factor receptor (EGFR)	MMAE; TOP1 inhibitor	Undisclosed	ADC Info

References

Ref 1	Innovent Biologics announced that the world's first CEACAM5 dual-payload ADC (IBI3020) has completed the first patient administration in its Phase I clinical study