Target Information

General Information of This Target

Target ID	PAYTAR0GLHTL
Target Name	Microtubule (MT)+DNA topoisomerase 1 (TOP1)

Full List of The ADC Related to This Target

Phase 1

Click To Hide/Show 1 ADC Related to This Stage

ADC Info	ADC Name	Antibody	Antigen	Payload	Linker	Ref
ADC Info	IBI3020	Anti-CEACAM5 antibody	CEACAM5	MMAE; TOP1 inhibitor	A cleavable linker	[1]

Phase 1

Click To Hide/Show 1 ADC Related to This Stage

ADC Info	ADC Name	Antibody	Antigen	Payload	Linker	Ref
ADC Info	iBI3028	Anti-EGFR/c-Met bsAb	EGFR; c-Met	MMAE; TOP1 inhibitor	Undisclosed

References

Ref 1	Innovent Biologics announced that the world's first CEACAM5 dual-payload ADC (IBI3020) has completed the first patient administration in its Phase I clinical study